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World Stroke Day: Breathing in low quality air can lead to stroke, warns doctor

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New Delhi, Oct 29: As today is World Stroke Day, doctors have warned that breathing in the low-quality air can cause a stroke.

Stroke is a medical condition in which brain cells die due to reduced blood supply. A stroke can be caused by blockage or rupture of the blood vessels supplying the brain.

Gaurav Thukral, Chief Operating Officer, HealthCare atHome, said in a statement: “Lack of awareness is a major cause of high DALYs (disability-adjusted life year) in India. In India, overall DALYs lost due to stroke are 795.57 per 100,000 person-years, which is very high.”

“People are unaware of the linkage of stroke with air pollution and often do not take the necessary steps to avoid it. Even after stroke attacks, people underestimate the importance of rehabilitation, which can be the key to complete recovery and low DALYs. For patients who cannot go to hospitals for regular physiotherapy sessions, home healthcare is the solution for them.”

Since prevention is always better than cure, it is important the people adapt themselves accordingly. Using masks while outdoors and using air purifiers at home can help people living in cities with moderate to high pollution. Indoor plants that reduce the pollution also come handy to breathe fresh air indoors.

According to Manreet Kahlon, COO, IVH Senior Care: “Respiratory conditions are often linked to air pollution. However, in the past decade or so evidence has emerged to link the air pollution to cardiovascular disease. The incidence of stroke is highest among low to medium income group countries because of high pollution on account of industrialisation.

“The importance of condition can be understood by the fact that air pollution qualifies to the top 5 list of risk factor associated with death in India.”

People must also be aware that when stroke strikes, early interventions can aid recovery. But for that, it is very important to recognise the early signs, which include an uneven smile, arm numbness and weakness, and slurred speech.

Vivek Tiwari, CEO, Medikabazar, said: “In the past, diagnosis and treatment of stroke were challenging. However, with the advancement in the medical technology and devices, the treatment is possible even in a small town. Advanced CT scan and MRI machines have helped in reaching the diagnosis promptly and advancement in procedures like balloon angiography has made it possible to prevent and treat stroke.”

“The procedure is safer than open heart surgery and offers better success rates.”

IANS

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Moderna Says Vaccine 100% Effective Against Severe Covid, Seeks Clearance

COVID-19 Vaccine: Moderna said it expects to have approximately 20 million doses of the vaccine, called mRNA-1273, available in the US by the end of the year.

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Washington: Moderna Inc will apply for US and European emergency authorization for its COVID-19 vaccine on Monday after full results from a late-stage study showed it was 94.1% effective with no serious safety concerns, the company said. Moderna also reported that the vaccine’s efficacy rate was consistent across age, race, ethnicity and gender demographics as well as having a 100% success rate in preventing severe cases of a disease that has killed nearly 1.5 million people.

The filing sets Moderna’s product up to be the second vaccine likely to receive US emergency use authorization this year following a shot developed by Pfizer and BioNTech which had a 95% efficacy rate in trials. “We believe that we have a vaccine that is very highly efficacious. We now have the data to prove it,” Moderna Chief Medical Officer Tal Zaks said.

“We expect to be playing a major part in turning around this pandemic.”

Of the 196 volunteers who contracted COVID-19 in the trial with more than 30,000 people, 185 received a placebo while 11 got the vaccine.

Moderna reported 30 severe cases — all in the placebo group — which means the vaccine was 100% effective in preventing severe cases.

“As the numbers of cases reported grows, confidence grows that this amazing protection will be maintained in a product that can be rolled out to protect the public,” said Alexander Edwards, associate professor in biomedical technology at Britain’s University of Reading.

In addition to filing its US application, Moderna said it would seek conditional approval from the European Medicines Agency, which has already begun a rolling review of its data, and would continue to talk with other regulators.

Pfizer has already applied for emergency use authorization in the United States and Europe, putting it about a week ahead of Moderna.

Moderna said it was on track to have about 20 million doses of its vaccine ready to ship in the United States by the end of 2020, enough to inoculate 10 million people.

Both of the vaccines use a new technology called synthetic messenger RNA (mRNA) whereas others, such as Britain’s AstraZeneca, are using more traditional methods to develop their vaccines.

AstraZeneca has announced an average efficacy rate of 70% for its shot and as much as 90% for a subgroup of trial participants who got a half dose, followed by a full dose.

But some scientists have expressed doubts about the robustness of the 90% efficacy figure for the smaller group.

Moderna’s latest efficacy result is slightly lower than an interim analysis released on Nov 16 of 94.5% effectiveness, a difference that Mr Zaks said was not statistically significant.

“At this level of effectiveness, when you just do the math of what it means for the pandemic that’s raging around us, it’s just overwhelming,” said Zaks, who said he cried when he saw the final results over the weekend.

Both the Moderna and Pfizer vaccines proved more effective than anticipated and were far superior to the 50% benchmark set by the US Food and Drug Administration (FDA).

The past few weeks of positive vaccine results have ignited hopes for an end to a pandemic that has battered economies and comes as new infections and COVID-19 hospitalizations are at record levels across the United States.

Independent advisers to the FDA are scheduled to meet on December 17 to review Moderna’s trial data and make a recommendation to the FDA.

They will meet on December 10 to review Pfizer’s data. Shortly after gaining emergency use authorization, Moderna expects the vaccine to be shipped to distribution points throughout the United States by the government’s Operation Warp Speed program and McKesson Corp, a drug distributor contracted by the US government.

Its distribution is expected to be easier than Pfizer’s because while it needs to be stored in a freezer, it does not require the ultra-cold temperature needed by Pfizer’s vaccine.

Moderna said the 196 COVID-19 cases in its trial included 33 adults over 65 years old and 42 volunteers from racially diverse groups, including 29 Latinos, 6 Blacks, 4 Asian Americans and 3 multiracial participants. There was one death related to COVID-19 in the placebo group.

Azra Ghani, chair in infectious disease epidemiology at Imperial College London, said Monday’s details from Moderna confirmed the vaccine was highly efficient, including against severe cases. “Whilst this does not exclude some risk of severe disease after vaccination given the relatively small number of severe cases, these results suggest very high efficacy,” she said.

Zaks said the vaccine has been developed during a period of “political acrimony” and having a highly effective vaccine may go a long way toward erasing some of that distrust. “This is as black and white as an effect on a population will be. Your chances of actually being sick if you’ve been vaccinated are decreased 20-fold,” he said.

Moderna reported no new side effects since its interim analysis. Based on that analysis, the most common side effects were fatigue, injection site redness and pain, headache and body aches, which rose after the second dose and were short-lived.

Zaks said the vaccine caused significant flu-like symptoms in some participants, which, he said, “goes hand-in-hand with having such a potent vaccine.” But it has not caused any significant safety concerns so far.

Moderna plans to start a new trial to test the vaccine in adolescents before the end of the year, followed by another in even younger volunteers early in 2021.

It hopes to have the vaccine available for adolescents by September, Zaks said.

Other vaccine makers have said they are studying their vaccines in young people as well.

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Modi interacts with 3 teams developing corona vaccines

The Prime Minister also asked the companies to come out with their suggestions and ideas regarding the regulatory processes and related matters.

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Narendra Modi

New Delhi, Nov 30: Prime Minister Narendra Modi on Monday held virtual meetings with three teams working on the development and manufacture of vaccines against Covid-19, and discussed the potential of various platforms for vaccine development.

The teams are from Gennova Biopharmaceuticals Ltd at Pune, and Biological E Ltd and Dr Reddy’s Laboratories Ltd at Hyderabad.

Their potential vaccines are in different stages of trials and detailed data and results are expected from early next year onwards, a Prime Minister’s Office (PMO) statement said on Monday.

“The potential of various platforms for vaccine development was also discussed,” the statement said.

The Prime Minister also asked the companies to come out with their suggestions and ideas regarding the regulatory processes and related matters.

He also suggested that they should make extra efforts to inform the general public in simple language about the vaccine and related matters such as its efficacy.

Matters relating to logistics, transport and cold chains in respect of delivery of the vaccines were also discussed.

The Prime Minister advised all departments concerned to engage with the manufacturers and seek to resolve matters so that the efforts by these companies bear fruit in order to serve the needs of the country and the entire world.

The Prime Minister praised the efforts made by scientists and researchers in these companies to come out with a vaccine solution to tackle the ongoing coronavirus pandemic, which so far has infected 94,31,692 people across the country, and led to deaths of 1,37,139 patients.

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With 38k new Covid-19 cases, India’s tally tops 94.3 lakhs

The recovery rate stands at 93.81 per cent, and the fatality rate is 1.45 as per cent, the Ministry said.

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DELHI-CORONAVIRUS

New Delhi, Nov 30: With 38,772 new coronavirus cases and 443 deaths in the past 24 hours, India’s overall tally stood at 94,31,692 on Monday, as the fatality toll touched 1,37,139, the Ministry of Health and Family Welfare said.

Currently, there are 4,46,952 active cases, whereas 8,84,76,00 patients have been cured and discharged so far.

The recovery rate stands at 93.81 per cent, and the fatality rate is 1.45 as per cent, the Ministry said.

“India continues to have one of the lowest deaths per million population globally (presently 99). Focussed measures to ensure a low and manageable fatality rate have resulted in daily mortality figures of less than 500,” it added.

Maharashtra continued to be the worst-hit state with 1,820,059 cases till date. There are 92,062 active cases and 47,071 Covid-19 deaths.

According to the Ministry, over 70 per cent of the daily new cases are contributed by eight States and UT i.e. Maharashtra, Delhi, Kerala, West Bengal, Rajasthan, Uttar Pradesh, Haryana, and Chhattisgarh.

The overall number of global coronavirus cases has topped 62.6 million, while the deaths have surged to more than 1.45 million, according to the Johns Hopkins University.

In its latest update on Monday, the University’s Center for Systems Science and Engineering (CSSE) revealed that the current global caseload and death toll stood at 62,670,153 and 1,458,360, respectively.

The US is the worst-hit country with the world’s highest number of cases and deaths at 13,374,162 and 266,838, respectively, according to the CSSE.

India comes in second place in terms of cases.

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