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Tiny bubbles in our body to fight cancer better than chemo

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New York, Sep 14  Researchers have found that tiny bubbles in our body might potentially be used to treat cancer and could fight the disease better than chemotherapy.

Healthy cells in our body release nano-sized bubbles that transfer genetic material such as DNA and RNA to other cells. It’s your DNA that stores the important information necessary for RNA to produce proteins and make sure they act accordingly.

According to the researchers, these bubbly extracellular vesicles (EV) could become mini treatment transporters, carrying a combination of therapeutic drugs and genes that target cancer cells and kill them.

The study, published in the journal Molecular Cancer Therapeutics, focused on breast cancer cells in mice.

“What we’ve done is improve a therapeutic approach to delivering enzyme-producing genes that can convert certain drugs into toxic agents and target tumours,” said the study’s lead author Masamitsu Kanada, Assistant Professor at the Michigan State University.

These drugs or prodrugs start out as inactive compounds. But once they metabolize in the body, they are immediately activated and can get to work on fighting everything from cancer to headaches.

Aspirin is an example of a common prodrug. In this case, researchers used EVs, to deliver the enzyme-producing genes that could activate a prodrug combination therapy of ganciclovir and CB1954 in breast cancer cells.

Minicircle DNA and regular plasmid – two different gene vectors that act as additional delivery mechanisms for DNA – were loaded into the vesicles to see which was better at helping transport treatment.

This is known as a gene-directed enzyme, prodrug therapy. They found that the minicircle DNA was 14 times more effective at delivery and even more successful at killing cancerous tumours.

“Conventional chemotherapy isn’t able to differentiate between tumours and normal tissue, so it attacks it all,” Kanada said.

With EVs, treatment can be targeted and because of their compatibility with the human body, this type of delivery could minimize the risk of unwanted immune responses that can come with other gene therapies.

“If EVs prove to be effective in humans, it would be an ideal platform for gene delivery and it could be used in humans sooner than we expect,” Kanada added.


India

President Kovind donates ₹5 lakh for Ram Temple construction

His Excellency Ram Nath Kovind along with his family donated in their individual capacity to the donation drive and conveyed their warm greetings for the nationwide fund campaign,” VHP President Alok Kumar said after receiving the donation from the President.

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Ram Nath Kovind

New Delhi, President Ram Nath Kovind has given the first donation for the construction of the grand Ram temple at Ayodhya in Uttar Pradesh. He donated ₹5,00,100 to a joint delegation of office bearers of the Rashtriya Swayamsevak Sangh (RSS), the Vishwa Hindu Parishad (VHP) and the Ram Mandir Trust at Rashtrapati Bhavan on Friday.

With this donation by President Kovind, the fund collection drive for the Ram temple started across the country. The campaign will run till February 27.
“We went to President Ram Nath Kovind for the launch of the Ram Mandir Fund Donation Drive. He donated Rs 5,00,100 under the Shri Ram Mandir Fund Donation Drive which kicked-off across the country from Friday. His Excellency Ram Nath Kovind along with his family donated in their individual capacity to the donation drive and conveyed their warm greetings for the nationwide fund campaign,” VHP President Alok Kumar said after receiving the donation from the President.

Vinod Bansal, the VHP national spokesperson, told that a massive public outreach campaign would be launched to cover 13 crore families across 5.25 lakh villages in the country for the construction of the grand Ram temple at Ayodhya. As many as 65 crore people from 13 crore families would be directly linked with the Ram Mandir fund donation drive.

The delegation to meet President Kovind comprised the treasurer of the Shri Ram Janmabhoomi Teerth Kshetra Trust, Govind Dev Giri Maharaj, VHP President Alok Kumar, Ram Mandir Construction Committee Chairman Nripendra Mishra and the Rashtriya Swayamsevak Sangh’s Delhi state Head Kulbhushan Ahuja.

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India

Makar Sankranti showcases India’s vibrancy of traditions: PM

“The festival also reaffirms the importance of respecting Mother Nature.”

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Narendra Modi

New Delhi, Jan 14 : Prime Minister Narendra Modi on Thursday extended his greetings to the people on Makar Sankranti and said that the festival showcases the vibrancy of traditions in India.

“Many congratulations to the countrymen on Makar Sankranti. I wish Uttarayan Suryadev to bring new energy and new enthusiasm in everyone’s life,” the Prime Minister tweeted.

Noting that Makar Sankranti is celebrated with enthusiasm in various parts of India, Modi said that the auspicious festival illustrates India’s diversity and the vibrancy of traditions.

“The festival also reaffirms the importance of respecting Mother Nature.”

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Entertainment

Disha Patani redefines fitness goals for fans

Disha will also be seen in “KTina”, produced by Ekta Kapoor. The film also features Akshay Oberoi and Sunny Singh.

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Disha Patani Fitness

Mumbai, Jan 14: Bollywood actress Disha Patani redefines her fitness goals for fans in a new workout video on social media.

In the clip she has posted on Instagram, Disha is seen doing Lat pulldown workout for her back. The actress chose a sloth emoji to caption her picture.

Disha will next be seen in “Radhe”, co-starring Salman Khan and Randeep Hooda. The film is directed by Prabhudeva.

She is also looking forward to reuniting with filmmaker Mohit Suri on the set of their next film, “Ek Villain 2”. The actress has earlier collaborated with Mohit on their 2020 film “Malang”.

Disha will also be seen in “KTina”, produced by Ekta Kapoor. The film also features Akshay Oberoi and Sunny Singh.

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