Tiny bubbles in our body to fight cancer better than chemo | WeForNews | Latest News, Blogs Tiny bubbles in our body to fight cancer better than chemo – WeForNews | Latest News, Blogs
Connect with us

Lifestyle

Tiny bubbles in our body to fight cancer better than chemo

Published

on

Cancer-banner png-min
File Photo

New York, Sep 14  Researchers have found that tiny bubbles in our body might potentially be used to treat cancer and could fight the disease better than chemotherapy.

Healthy cells in our body release nano-sized bubbles that transfer genetic material such as DNA and RNA to other cells. It’s your DNA that stores the important information necessary for RNA to produce proteins and make sure they act accordingly.

According to the researchers, these bubbly extracellular vesicles (EV) could become mini treatment transporters, carrying a combination of therapeutic drugs and genes that target cancer cells and kill them.

The study, published in the journal Molecular Cancer Therapeutics, focused on breast cancer cells in mice.

“What we’ve done is improve a therapeutic approach to delivering enzyme-producing genes that can convert certain drugs into toxic agents and target tumours,” said the study’s lead author Masamitsu Kanada, Assistant Professor at the Michigan State University.

These drugs or prodrugs start out as inactive compounds. But once they metabolize in the body, they are immediately activated and can get to work on fighting everything from cancer to headaches.

Aspirin is an example of a common prodrug. In this case, researchers used EVs, to deliver the enzyme-producing genes that could activate a prodrug combination therapy of ganciclovir and CB1954 in breast cancer cells.

Minicircle DNA and regular plasmid – two different gene vectors that act as additional delivery mechanisms for DNA – were loaded into the vesicles to see which was better at helping transport treatment.

This is known as a gene-directed enzyme, prodrug therapy. They found that the minicircle DNA was 14 times more effective at delivery and even more successful at killing cancerous tumours.

“Conventional chemotherapy isn’t able to differentiate between tumours and normal tissue, so it attacks it all,” Kanada said.

With EVs, treatment can be targeted and because of their compatibility with the human body, this type of delivery could minimize the risk of unwanted immune responses that can come with other gene therapies.

“If EVs prove to be effective in humans, it would be an ideal platform for gene delivery and it could be used in humans sooner than we expect,” Kanada added.


India

Andhra Pradesh Govt puts plans to sell Tirumala Tirupati Devasthanam properties on hold

Published

on

By

Tirumala Tirupati Devasthanam

Amaravati, 25 May : The government of Andhra Pradesh on Monday stepped in to put on hold the proposed sale of unviable assets belonging to the Tirumala Tirupati Devasthanam (TTD). The state government stepped in to control the damage following the rising resentment in several quarters over the recent move by the Board of Trustees of the TTD.

In an order issued by Praveen Prakash, Principal Secretary (Political), on Monday, the state government, keeping in view devotees’ sentiments, directed the TTD to re-examine the issue in consultation with the different stakeholders such as religious elders, opinion makers, section of devotees etc., to ascertain whether these properties can be used by TTD for construction of temples, dharma pracharam and other religious activities.

The state government headed by Chief Minister Y.S. Jagan Mohan Reddy has been at the receiving end of opposition parties over the move to dispose of 50 TTD properties located in Tamil Nadu and other places outside Andhra Pradesh. The state government has pointed out that the controversial decision was in fact taken during the previous regime headed by the Telugu Desam Party.

“It has been brought to the notice of the government that the Board of Trustees of Tirumala Tirupati Devasthanam (TTD), which was constituted by the previous government, approved the disposal of 50 properties of TTD through its resolution No. 253 dated 30.01.2016,” the order pointed out.

The richest religious body in the country, the TTD has been in the news of late with reports of a cash crunch following the Covid-19 induced lockdown and the resultant freeze on contributions from the devotees. The TTD is headed by Y.V. Subba Reddy, who is also Jagan Mohan Reddy’s maternal uncle.

Continue Reading

Health

Young adults more likely to die from epilepsy: Study

Published

on

By

Brain.

London, May 25 (IANS) A new study has claimed that young adults aged between 16 and 24 may have a six-fold increased risk of epilepsy-related death, a disorder in which nerve cell activity in the brain is disturbed, causing seizures.

The study, presented at the European Academy of Neurology (EAN) Virtual Congress, found that mortality rates for epilepsy-related deaths did not decrease between 2009 (6.8 per 100,000) and 2015 (9.1 per 100,000), despite advances in treatment during this time.

Young adult patients in their early 20s and 30s were found to be at the highest risk, with 78 per cent of epilepsy-related deaths under the age of 55 years classified as potentially avoidable.

The study, being conducted in Scotland, aims identify the burden of epilepsy-related deaths, what proportion of these are potentially avoidable, and ascertain the factors that may put patients at an increased risk.

“Epilepsy patients are at a higher risk of early death than the general population, but reasons for this are unclear,” said study researcher Gashirai Mbizvo from the University of Edinburgh in Scotland.

“We hope that we can use this data to learn lessons and reduce the burden of epilepsy-related deaths in the future, many of which we believe are likely to be avoidable,” Mbizvo added.

Epilepsy is a chronic noncommunicable disease of the brain that affects around 50 million people globally, making it one of the most common neurological diseases worldwide.

For the findings, the researchers collected anonymous data from healthcare settings for patients that died between 2009 and 2016, identifying 2,149 epilepsy-related deaths.

At least 60 per cent of these patients (1,276) had one or more seizure-related or epilepsy-related hospital admission in the years prior to death, yet less than a quarter (516) were seen in a neurology clinic.

The most common causes of death within the study were sudden unexpected death in epilepsy (SUDEP), aspiration pneumonia, cardiac arrest, congenital malformation and alcohol-related deaths.

The data will be compared with data from living patients with epilepsy of the same age and gender.

“Highlighting such risk factors, and identifying those that could be prevented, might lead to changes in epilepsy care and, ultimately, fewer epilepsy-related deaths in the future,” the researchers noted.

Continue Reading

Cities

Delhiites brace for an Eid at home amid Covid-19 pandemic

Published

on

By

Lockdown Eid

New Delhi, May 24 : Observe Eid with simplicity, help your neighbour and feed the hungry. This seems to be the message this Eid ul-Fitr, at least in the national capital.

With assemblies prohibited and all religious places closed amid the nationwide lockdown due to Covid-19 pandemic, Delhiites are bracing for an Eid at home, and so do religious leaders appeal for.

Stating that Eid means happiness, Umer Ahmed Ilyasi, Chief Imam of the All India Imam Organization (AIIO), told IANS, “Happiness is possible only when others are happy as well. We are facing an unprecedented situation. I have appealed against buying new clothes and observing Eid by staying home.”

Every year visuals of thousands offering namaaz at Delhi’s iconic Jama Masjid showcases Eid. But this year the vast expanse of the mosque will remain empty. Shahi Imam of Jama Masjid Ahmad Bukhari have asked people to offer prayers at their homes.

“I appeal to all the faithful to maintain social distancing and stay indoors during the Eid festivities,” Bukhari said. He urged them to extend a helping hand to the poor, the destitute and the needy in this hour of crisis, as hundreds and thousands were staring at an uncertain future.

Despite relaxations, footfall in most markets have been minimal due to the fear of infection. With restaurants not allowed to serve food, most traditional Mughlai eateries in the bylanes of Jama Masjid are likely to either remain shut or open only to provide home delivery.

One of the biggest Muslim festival, Eid ul-Fitr marks the end of the holy month of Ramzan. It’s normally celebrated with exchange of greetings, hugs, feasting and bonding. But due to the lockdown and corona scare, this Eid is likely to be muted.

Union Minority Affairs Minister Mukhtar Abbas Naqvi tweeted that though for the first time he would offer prayer and celebrate Eid at home due to the pandemic, it would not affect the festive spirit.

Bharatiya Janata Party (BJP) leader Shahnawaz Hussain, known for organising sumptuous Eid feast in the Lutyens Delhi, which is attended by top politicians cutting across political affiliations, journalists and other dignitaries, will also be observing a quiet Eid.

“I have been doing this Eid luncheon for 21 years. But this time things are different. No invitation has been sent. I will spend Eid in a simple way by distributing food among the poor,” said Hussain.

While the grandeur will be amiss this year, religious leaders insist it’s the intent that counts. They say, new clothes or a grand buffet is not what makes Eid special, it’s the happiness that counts, which increases manifold when shared with others.

Continue Reading
Advertisement

Most Popular