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Soybean oil diet may trigger genetic changes in brain

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New York, Widely consumed soybean oil not only leads to obesity and diabetes but may also affect neurological conditions like autism, Alzheimer’s disease, anxiety and depression, report researchers from University of California Riverside, including one of Indian origin.

In a study conducted on mice, the scientists found pronounced effects of the soybean oil on the hypothalamus where a number of critical processes take place. The research team discovered nearly 100 genes – including the ‘love hormone’ oxytocin produced in hypothalamus — affected by the soybean oil diet.

“The hypothalamus regulates body weight via your metabolism, maintains body temperature, is critical for reproduction and physical growth as well as your response to stress,” said Margarita Curras-Collazo, an associate professor of neuroscience and lead author on the study published in the journal Endocrinology.

The research team has not yet isolated which chemicals in the oil are responsible for the changes they found in the hypothalamus.

“But they have ruled out two candidates. It is not linoleic acid, since the modified oil also produced genetic disruptions; nor is it stigmasterol, a cholesterol-like chemical found naturally in soybean oil,” the study noted.

Identifying the compounds responsible for the negative effects is an important area for the team’s future research.This could help design healthier dietary oils in the future,” said Poonamjot Deol, first author on the study.

“If there’s one message I want people to take away, it’s this: reduce consumption of soybean oil,” Deol added.The team compared mice fed three different diets high in fat: soybean oil, soybean oil modified to be low in linoleic acid, and coconut oil.

They believe this discovery could have ramifications not just for energy metabolism,but also for proper brain function and diseases such as autism or Parkinson’s disease.

“However, it is important to note there is no proof the oil causes these diseases,” the authors wrote.

Te same research team found in 2015 that soybean oil induces obesity, diabetes, insulin resistance, and fatty liver in mice. Then in a 2017 study, the same group learned that if soybean oil is engineered to be low in linoleic acid, it induces less obesity and insulin resistance.

The team said the findings only apply to soybean oil — not to other soy products or to other vegetable oils.Do not throw out your tofu, soymilk, edamame, or soy sauce,” said Frances Sladek, a UCR toxicologist and professor of cell biology.

“Many soy products only contain small amounts of the oil, and large amounts of healthful compounds such as essential fatty acids and proteins”.

This study utilized male mice. Because oxytocin is so important for maternal health and promotes mother-child bonding, similar studies need to be performed using female mice.

Coconut oil, which contains saturated fats, produced very few changes in the hypothalamic genes, said the researchers.

Health

The goodness of Argan oil

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Argan oil has traditionally been used topically to improve the health of skin, hair, and nails. It contains a number of different beneficial properties and vitamins that form a powerful combination to boost skin health.

Dr Geeta Grewal – cosmetic surgeon, beauty and health wellness expert explains some prominent uses of the oil for health, skin and hair.

Night Moisturiser

Argan oil absorbs quickly and does not leave an oily residue. In the winter months you may need a second drop but remember to use sparingly. This oil is safe and gentle to use around your eyes. Vitamin A and Vitamin E present in the oil can help to reduce fine wrinkles and keep this delicate area moisturized.

Skin Toner

Toning is an important step in your skin care routine. For an all-over glow, add 3-4 drops of your favourite toner, make your own chemical-free, natural toner at home.

Exfoliant

To experience the argon oil benefits while exfoliating, pay special attention to acne-prone areas and areas that are dry.

Regular exfoliation helps to remove dead skin cells and reduce the appearance of fine lines and wrinkles, while giving you a younger, fresher complexion. With the aid of the brown sugar, argon oil’s nutrients are more readily absorbed into your skin. Use this exfoliator for more than just your face. If you have dry elbows or heels, mix up a bit more to massage the dry and dead skin away.

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Health

Natural antioxidants can keep heart, cancer diseases at bay

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If you want to keep your immune system strong for fighting cardiovascular diseases or cancer, start taking natural antioxidants as health experts on Sunday stressed that it helps in improving overall health by providing many other health benefits.

According to experts, antioxidants are substances that may protect your cells against free radicals, which play a role in heart disease, cancer and other diseases.

Free radicals are molecules produced when your body breaks down food or when you’re exposed to tobacco smoke or radiation.

The latest antioxidant which is produced for the first time in India is gamma oryzanol, which is very quickly gaining popularity as a super antioxidant.

It is a substance that is taken out of rice bran oil. It is also found in wheat bran and some fruits and vegetables.

The experts said that gamma oryzanol is used for high cholesterol, symptoms of menopause and many other conditions.

“Gamma oryzanol is useful for controlling elevated cholesterol and triglyceride levels, supporting cardiovascular health along with controlling menopausal symptoms. Gamma oryzanol helps lower cholesterol because it helps decrease cholesterol absorption and increase cholesterol elimination. Along with this, it is also known to boost metabolic rate and may help with weight loss,” Swapna Chaturvedi, senior dietician, Department of Dietetics, AIIMS told IANS.

As gamma oryzanol is found to be effective in controlling high cholesterol level in the body, it is registered in Japan and the US as a natural medicine to treat hyperlipidemia/dyslipidaemia (elevated cholesterol levels/unhealthy cholesterol levels.

Most research shows that taking natural antioxidants decreases total cholesterol, “bad” low-density lipoprotein (LDL) cholesterol, and blood fats called triglycerides in people with high cholesterol.

“It also helps in preventing heart attack by preventing platelet aggregation, a system where platelets blood gets stuck together and form clots that block arteries,” said Praveen Chandra, Head of Department, Interventional Cardiology, Medanta, The Medicity in Gurugram.

The experts mentioned that gamma oryzanol is also used for increasing testosterone and human growth hormone levels, as well as improving strength during resistance exercise training.

Gamma oryzanol also helps to inhibit different cancers in the body and builds immunity to fight cancer cells.

“Many of the antioxidants have proven beneficial in inhibiting the cancers at various stages. Gamma oryzanol has been found out to be effective antioxidant which comes from rice bran and helps in preventing cancer if taken for a long period,” said Rahul Bhargava, Director, Institute of Blood Disorder and BMT, Fortis Hospital, New Delhi.

Gamma oryzanol is basically activator of NK cells which gives the cancer cells a check.

It not only works through NK cells but also inhibits angiogenesis. It means it cuts the supply for the cancer cells to grow and increases your body’s own immunity to gather the strength to kill cancers.

“Gamma oryzanol also prevents cancers and studies show it helps in regressing the prostate cancer cells,” Bhargava noted.

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Male sex hormones may help treat breast cancer: Study

While endocrine therapy is standard-of-care for estrogen receptor positive breast cancer, resistance to these drugs is the major cause of breast cancer mortality.

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Sydney : Researchers have found new evidence about the positive role of androgens, commonly thought of as male sex hormones but also found at lower levels in women, in breast cancer treatment.

In normal breast development, estrogen stimulates and androgen inhibits growth at puberty and throughout adult life.

Abnormal estrogen activity is responsible for the majority of breast cancers, but the role of androgen activity in this disease has been controversial.

The new research published in the journal Nature Medicine showed that androgens have potential for treatment of estrogen receptor positive breast cancer.

A cancer is called estrogen receptor positive if it has receptors for estrogen, according to Breastcancer.org.

Using cell-line and patient-derived models, the global team, including researchers at the University of Adelaide and the Garvan Institute of Medical Research in Australia, demonstrated that androgen receptor activation by natural androgen or a new androgenic drug had potent anti-tumour activity in all estrogen receptor positive breast cancers, even those resistant to current standard-of-care treatments.

In contrast, androgen receptor inhibitors had no effect.

“This work has immediate implications for women with metastatic estrogen receptor positive breast cancer, including those resistant to current forms of endocrine therapy,” said lead researcher Theresa Hickey, Associate Professor at the University of Adelaide.

“We provide compelling new experimental evidence that androgen receptor stimulating drugs can be more effective than existing (e.g. Tamoxifen) or new (e.g. Palbociclib) standard-of-care treatments and, in the case of the latter, can be combined to enhance growth inhibition,” said Wayne Tilley, Director of the Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide.

Androgens were historically used to treat breast cancer, but knowledge of hormone receptors in breast tissue was rudimentary at the time and the treatment’s efficacy misunderstood.

Androgen therapy was discontinued due to virilising side effects and the advent of anti-estrogenic endocrine therapies.

While endocrine therapy is standard-of-care for estrogen receptor positive breast cancer, resistance to these drugs is the major cause of breast cancer mortality.

“The new insights from this study should clarify the widespread confusion over the role of the androgen receptor in estrogen receptor driven breast cancer,” said Elgene Lim, a breast oncologist and Head of the Connie Johnson Breast Cancer Research Lab at the Garvan Institute.

“Given the efficacy of this treatment strategy at multiple stages of disease in our study, we hope to translate these findings into clinical trials as a new class of endocrine therapy for breast cancer.”

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