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Seriously ill Covid-19 patients’ antibodies affect immune system: Study

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London, Oct 16 : Researchers have found that people seriously ill with the Covid-19 disease have antibodies that are blocking so-called interferons, which are an important part of the body?s immune mechanism.

While most people dying from Covid-19 are elderly, up to five to 10 per cent of younger adults and children can also be seriously infected by the SARS-CoV-2 virus, the study, published in the journal Science, reported.

Researchers from all over the world have tried to determine why some people become very ill and others are barely affected by Covid-19.

“Deaths and severe Covid-19 are more frequent among men than women. Our study has shown that men have more of these antibodies,” said study author Eystein Husebye from the University of Bergen in Norway.

Husebye was involved in this study because he has had long experience with patients suffering from the immune disease APS1.

APS1 is a serious, but rare, immune disease. Patients with APS1 have a high concentration of antibodies against interferons.

If these patients then become infected with Covid-19, their bodies will work against their own immune systems. In addition, this response has also been seen in patients with milder immune diseases.

“It is relatively easy to see if young people with Covid-19 have these antibodies in their blood. If so, it might be possible to supply them with extra interferons as treatment,” Husebye said.

Even if it is easy to use blood tests to discover antibodies against interferons, the author does not recommend massive screening of healthy people.

Most people with APS1 are diagnosed in their childhood, and most people with immune failure have been diagnosed already.

“Immune failure is just a piece in the puzzle when it comes to understanding why young people may die of Covid-19. Old people generally die of more complex causes,” the authors wrote.

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Researchers identify new drug to treat COVID-19 patients

In the continuing fight against the novel Coronavirus, researchers have now identified a drug with the potential to provide treatment for COVID-19 close to a year after it turned into a pandemic

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In the continuing fight against the novel Coronavirus, researchers have now identified a drug with the potential to provide treatment for COVID-19 close to a year after it turned into a pandemic.

The study, published in the journal Cells, found that the approved protease inhibitor aprotinin displayed activity against SARS-CoV-2, the coronavirus that causes COVID-19, in concentrations that are achieved in patients.

According to the researchers, aprotinin aerosols are approved in Russia for the treatment of influenza and could be readily tested for the treatment of COVID-19.

Aprotinin inhibits the entry of SARS-CoV-2 into host cells and may compensate for the loss of host cell protease inhibitors that are downregulated upon SARS-CoV-2 infection.

“The aprotinin aerosol has been reported to be tolerated extremely well in influenza patients. Hence, it may have a particular potential to prevent severe COVID-19 disease when applied early after diagnosis,” said study author Martin Michaelis from the University of Kent in the UK.

“Aprotinin has previously been shown to inhibit TMPRSS2 gene and has been suggested as a treatment option for influenza viruses and coronaviruses. Herein, we investigated the effects of aprotinin against SARS-CoV-2,” Michaelis added.

The findings showed that aprotinin displayed anti-SARS-CoV-2 activity in different cell types (Caco2, Calu-3, and primary bronchial epithelial cell air-liquid interface cultures) and against four virus isolates.

“An approved aprotinin aerosol may have the potential for the early local control of SARS-CoV-2 replication and the prevention of COVID-19 progression to a severe, systemic disease,” the study authors noted.

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No dengue death in Delhi this year

Delhi govt announced zero death in the national capital due to dengue this year so far, giving credit to CM Kejriwal’s campaign against the mosquito-borne tropical disease caused by the dengue virus

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Arvind Kejriwal

Delhi government on Saturday announced zero death in the national capital due to dengue this year so far, giving credit to Chief Minister Arvind Kejriwal’s campaign against the mosquito-borne tropical disease caused by the dengue virus.

The announcement comes as it is going to organise the ninth week of ’10 Hafte 10 Baje, 10 Minute’ anti-dengue campaign on Sunday with Delhi Chief Minister Arvind Kejriwal appealing the citizen to join the movement.

“This is the second last week of the campaign and due to the aggressive campaign by the Delhi government this year no dengue-related death has been reported in the national capital,” the government said in a statement.

This week Delhi Health Minister Satyendar Jain also informed that no dengue-related death has been reported in the national capital this year and credited Kejriwal government’s anti-dengue campaign for this.

“Delhi people did it! No death due to dengue this year. There is also a sharp fall in number of cases compared to figures reported last year. Chief Minister Arvind Kejriwal’s campaign — ’10 hafte 10 baje 10 minute’ — has been made a success by you all,” Jain had tweeted.

As per the Delhi government statement, the Delhi model of fighting dengue is getting applauded across the country and Bollywood actor Amitabh Bachchan recently asked a question about the campaign to a contestant by playing a voice clip of the Delhi Chief Minister in the popular television show KBC.

Delhi Chief Minister Kejriwal earlier had urged citizens here for their collective efforts against the disease, saying “we have to stop the breeding of dengue mosquitoes and protect our family and the entire Delhi from Dengue.”

Kejriwal on last Sunday had also declared that dengue was “under control” in the national capital like previous year.

Last week, the anti-dengue campaign of the Delhi government got support from celebrities such as Shankar Mahadevan, who encouraged the citizens of Delhi to religiously follow the dengue prevention guidelines such as inspecting their residences for signs of stagnant water, draining the accumulated water or adding a layer of oil or petrol to it to prevent the breeding of mosquitoes.

The Delhi government this year launched a Dengue helpline — 01123300012 — and a WhatsApp helpline — 8595920530 — to assist the general public.

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Sero Survey In Bhubaneswar: 50% Residents Develop Antibodies To Fight Coronavirus

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Coronavirus outbreak

Bhubaneswar: Half of the residents of Bhubaneswar have developed antibodies to fight novel Coronavirus. The statistics were revealed by ICMR – Regional Medical Research Centre (RMRC) Director, Dr Sanghamitra Pati today. Dr Pati said the survey was carried out between October 16 and 18 during which 1,400 samples were taken from all wards of Bhubaneswar Municipal Corporation (BMC).

As per the results, 50 per cent of Bhubaneswar’s population have been exposed to COVID-19, which means these many number of people now have the antibodies against the viral disease. “The results of the third sero survey corresponds to the status of infection, at least three weeks prior. So, there is much likelihood that exposure of people here to COVID-19 would have increased by now (October-end),” she said.

The good news is that 90 per cent of the people who are exposed to COVID-19 have very less or no symptoms. This implies that their immune system has been successful in fighting novel Coronavirus. Besides, 30 per cent of the people whose samples were collected have been tested through Rapid Antigen or RT-PCR, said Dr Pati.

Only around 2 per cent of Bhubaneswar’s population was found to be exposed to COVID-19 in the first sero survey. In the second survey in the last week of August, 5.1 per cent of the city’s population was exposed. Now, the result of the third sero survey is very encouraging, she said.

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