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Saudi Arabia, the Largest Producer of Oil, Will Now Create a City Without Cars or Roads

A Saudi statement said construction would start in the first quarter of 2021 and that the city was expected to contribute $48 billion to the kingdom’s gross domestic product and create 380,000 jobs.

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Saudi Arabia‘s Crown Prince Mohammed bin Salman has come out with his latest vision for the nation which is the largest producer of oil – an ambitious non-carbon emissions city without cars or roads.

The project named “The Line” will be home to a million people and have no cars and no streets, Crown Prince Mohammed bin Salman said, Arab News reported. “The city will be a 170 kilometer belt of “hyper-connected future communities,” and will be built around the natural environment,” he said.

Prince Mohammed said there was a need to transform the concept of a conventional city into that of a futuristic one. “By 2050, one billion people will have to relocate due to rising CO2 emissions and sea levels. 90 per cent of people breathe polluted air,” he added.

“Why should we sacrifice nature for the sake of development? Why should seven million people die every year because of pollution? Why should we lose one million people every year due to traffic accidents? And why should we accept wasting years of our lives commuting?” he said, according to the report.

The project is part of the prince’s plans to build a zero-carbon city at NEOM, the first major construction project for the $500 billion flagship business zone aimed at diversifying the nation’s economy.

The prince later told reporters in the northwestern city of Al Ula that the project was the conclusion of three years of preparation, adding that its infrastructure would cost $100 billion to $200 billion.

“The backbone of investment in ‘The Line’ will come from the $500 billion support to NEOM by the Saudi government, PIF and local and global investors over 10 years,” he added.

The kingdom’s sovereign wealth fund, the Public Investment Fund (PIF), is the cornerstone investor in NEOM, a 26,500-square-km (10,230-square-mile) high-tech development on the Red Sea with several zones, including an industrial and logistics areas, planned for completion in 2025.

There have been few announcements regarding NEOM since it was announced by de facto ruler Prince Mohammed to much fanfare in 2017 as a pillar of his Vision 2030 plan to rid Saudi Arabia of its reliance on crude oil revenues.

A Saudi statement said construction would start in the first quarter of 2021 and that the city was expected to contribute $48 billion to the kingdom’s gross domestic product and create 380,000 jobs.

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Male sex hormones may help treat breast cancer: Study

While endocrine therapy is standard-of-care for estrogen receptor positive breast cancer, resistance to these drugs is the major cause of breast cancer mortality.

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Sydney : Researchers have found new evidence about the positive role of androgens, commonly thought of as male sex hormones but also found at lower levels in women, in breast cancer treatment.

In normal breast development, estrogen stimulates and androgen inhibits growth at puberty and throughout adult life.

Abnormal estrogen activity is responsible for the majority of breast cancers, but the role of androgen activity in this disease has been controversial.

The new research published in the journal Nature Medicine showed that androgens have potential for treatment of estrogen receptor positive breast cancer.

A cancer is called estrogen receptor positive if it has receptors for estrogen, according to Breastcancer.org.

Using cell-line and patient-derived models, the global team, including researchers at the University of Adelaide and the Garvan Institute of Medical Research in Australia, demonstrated that androgen receptor activation by natural androgen or a new androgenic drug had potent anti-tumour activity in all estrogen receptor positive breast cancers, even those resistant to current standard-of-care treatments.

In contrast, androgen receptor inhibitors had no effect.

“This work has immediate implications for women with metastatic estrogen receptor positive breast cancer, including those resistant to current forms of endocrine therapy,” said lead researcher Theresa Hickey, Associate Professor at the University of Adelaide.

“We provide compelling new experimental evidence that androgen receptor stimulating drugs can be more effective than existing (e.g. Tamoxifen) or new (e.g. Palbociclib) standard-of-care treatments and, in the case of the latter, can be combined to enhance growth inhibition,” said Wayne Tilley, Director of the Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide.

Androgens were historically used to treat breast cancer, but knowledge of hormone receptors in breast tissue was rudimentary at the time and the treatment’s efficacy misunderstood.

Androgen therapy was discontinued due to virilising side effects and the advent of anti-estrogenic endocrine therapies.

While endocrine therapy is standard-of-care for estrogen receptor positive breast cancer, resistance to these drugs is the major cause of breast cancer mortality.

“The new insights from this study should clarify the widespread confusion over the role of the androgen receptor in estrogen receptor driven breast cancer,” said Elgene Lim, a breast oncologist and Head of the Connie Johnson Breast Cancer Research Lab at the Garvan Institute.

“Given the efficacy of this treatment strategy at multiple stages of disease in our study, we hope to translate these findings into clinical trials as a new class of endocrine therapy for breast cancer.”

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Elizabeth Olsen: Nepotism creates fear that you don’t deserve the work you get

The actress added that she “always had this need to prove myself to everyone around me that I work really hard”, adding: “I couldn’t walk in a room without everyone already having an opinion.”

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Los Angeles, Jan 19 : Hollywood star Elizabeth Olsen says she once thought of changing her surname and distance herself from the success of her family because it was insanity growing up in the spotlight.

“It was insanity. There were times when my sisters would always be spotted and I would be in the car with them and it would really freak me out. It has helped me navigate how I want to approach my career,” said the actress, whose older sisters are Mary-Kate Olsen and Ashley Olsen.

The actress added that she “always had this need to prove myself to everyone around me that I work really hard”, adding: “I couldn’t walk in a room without everyone already having an opinion.”

Elizabeth opened up om the fears of nepotism.

“The thing about nepotism is the fear that you don’t earn or deserve the work. There was even a part of me when I was a little girl that thought if I’m gonna be an actress I’m going to go by Elizabeth Chase, which is my middle name. And then, once I started working, I was like, ‘I love my family, I like my name, I love my sisters. Why would I be so ashamed of that?’ It’s fine now,” she said.

The actress said fame has made her more of a homebody.

“Fame has also made me someone who is more of a homebody than maybe I would like to be but I know where not to go. If I could do whatever I wanted for the day, I’d start with the gym, then I’d go to the grocery store, because it’s my favourite thing,” Elizabeth told The Sun.

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Bill Gates is America’s biggest farmland owner

Microsoft founder and philanthropist Bill Gates owns the largest chunk of private farmland in the US across 18 states, a new report has revealed.

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San Francisco: Bill and Melinda Gates amassed 242,000 acres of land in the US, with the largest holdings in Louisiana (69,071 acres), Arkansas (47,927 acres) and Nebraska (20,588 acres), according to The Land report.

Bill Gates also owns a stake in more than 24,800 acres of transitional land outside of Phoenix.

Research indicated that the lands across the US is held by Cascade Investment LLC, Gates’ private investment vehicle.

“Gates also backs online used-car seller Vroom through Cascade as well as the Canadian National Railway Company,” Geek Wire reported.

According to the Tri-City Herald, a 14,500-acre swath of choice Eastern Washington farmland in the Horse Heaven Hills in Benton County has just traded hands for almost $171 million – part of Gates’ holdings.

It is unclear why Gates has invested so heavily in farmland, but it could be connected to climate change.

The Bill & Melinda Gates Foundation launched a new nonprofit group a year ago, focused on helping small-scale farmers in developing countries with the tools and innovations they’ll need to deal with the effects of climate change.

Bill Gates is currently at the third spot on the Bloomberg Billionaires Index with a net worth of $132 billion.

But even with his big new agricultural holdings, Gates still doesn’t rank in the Top 100 private landowners overall in the US, considering owners of land of all types.

The list is topped by Liberty Media’s John Malone, with 2.2 million acres of ranches and forests. Amazon CEO Jeff Bezos makes that list at No. 25 with 420,000 acres.

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