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Researchers explain why cancer risk is higher in males

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London, DNA differences between men and women may explain why cancer risk is higher in males, according to a new study.

In findings published in the Journal of the National Cancer Institute, researchers have reported that loss of function in certain genes of the sex-determining Y chromosome, which is present only in men, may cause them to have an elevated risk for cancer.

Using data from 9,000 individuals, the researchers studied Y-chromosome gene function in patients with various types of cancer. The findings showed that cancer risk increases with loss of function of six key Y-chromosome genes in various types of cells.

“Recent studies have shown that complete loss of the Y chromosome, which is essential to foetal sex differentiation, occurs, with aging, in the cells of some men,” said study author Juan Ramon Gonzalez from Barcelona Institute for Global Health in Spain.

“Although the loss of the Y chromosome has previously been associated with higher incidence of cancer, the causes of this association are poorly understood,” Gonzalez added.

These six Y-chromosome genes are involved in cell-cycle regulation, the failure of which can lead to tumour development.

According to the study, understanding the biological differences between men and women in cancer is crucial for the development of personalised lines of treatment and prevention.

“Men are not only at higher risk of cancer than women, they also face a worse prognosis. In fact, these differences partially account for the lower life expectancy of men,” Gonzalez added.

According to the researchers, although men may be more exposed to carcinogens due to the type of work they do and at higher risk because they are less likely to consult a doctor, the study has shown that there are also biological factors that increase cancer risk among men.

“In fact, it seems that one of these factors can be found in the Y chromosome, the very essence of maleness,” said study lead author Alejandro Caceres.

Suppression of the Y chromosome can occur as a result of loss of function in the chromosome, which would explain previous findings, or as a result of other mechanisms mediated by the chemical (epigenetic) inactivation of the same regions, the research said.

“Certain environmental exposures, for example to tobacco or other harmful substances, could affect chromosome function and lead to epigenetic modifications,” Gonzalez said.

India

President Kovind donates ₹5 lakh for Ram Temple construction

His Excellency Ram Nath Kovind along with his family donated in their individual capacity to the donation drive and conveyed their warm greetings for the nationwide fund campaign,” VHP President Alok Kumar said after receiving the donation from the President.

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Ram Nath Kovind

New Delhi, President Ram Nath Kovind has given the first donation for the construction of the grand Ram temple at Ayodhya in Uttar Pradesh. He donated ₹5,00,100 to a joint delegation of office bearers of the Rashtriya Swayamsevak Sangh (RSS), the Vishwa Hindu Parishad (VHP) and the Ram Mandir Trust at Rashtrapati Bhavan on Friday.

With this donation by President Kovind, the fund collection drive for the Ram temple started across the country. The campaign will run till February 27.
“We went to President Ram Nath Kovind for the launch of the Ram Mandir Fund Donation Drive. He donated Rs 5,00,100 under the Shri Ram Mandir Fund Donation Drive which kicked-off across the country from Friday. His Excellency Ram Nath Kovind along with his family donated in their individual capacity to the donation drive and conveyed their warm greetings for the nationwide fund campaign,” VHP President Alok Kumar said after receiving the donation from the President.

Vinod Bansal, the VHP national spokesperson, told that a massive public outreach campaign would be launched to cover 13 crore families across 5.25 lakh villages in the country for the construction of the grand Ram temple at Ayodhya. As many as 65 crore people from 13 crore families would be directly linked with the Ram Mandir fund donation drive.

The delegation to meet President Kovind comprised the treasurer of the Shri Ram Janmabhoomi Teerth Kshetra Trust, Govind Dev Giri Maharaj, VHP President Alok Kumar, Ram Mandir Construction Committee Chairman Nripendra Mishra and the Rashtriya Swayamsevak Sangh’s Delhi state Head Kulbhushan Ahuja.

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India

Makar Sankranti showcases India’s vibrancy of traditions: PM

“The festival also reaffirms the importance of respecting Mother Nature.”

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Narendra Modi

New Delhi, Jan 14 : Prime Minister Narendra Modi on Thursday extended his greetings to the people on Makar Sankranti and said that the festival showcases the vibrancy of traditions in India.

“Many congratulations to the countrymen on Makar Sankranti. I wish Uttarayan Suryadev to bring new energy and new enthusiasm in everyone’s life,” the Prime Minister tweeted.

Noting that Makar Sankranti is celebrated with enthusiasm in various parts of India, Modi said that the auspicious festival illustrates India’s diversity and the vibrancy of traditions.

“The festival also reaffirms the importance of respecting Mother Nature.”

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Entertainment

Disha Patani redefines fitness goals for fans

Disha will also be seen in “KTina”, produced by Ekta Kapoor. The film also features Akshay Oberoi and Sunny Singh.

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Disha Patani Fitness

Mumbai, Jan 14: Bollywood actress Disha Patani redefines her fitness goals for fans in a new workout video on social media.

In the clip she has posted on Instagram, Disha is seen doing Lat pulldown workout for her back. The actress chose a sloth emoji to caption her picture.

Disha will next be seen in “Radhe”, co-starring Salman Khan and Randeep Hooda. The film is directed by Prabhudeva.

She is also looking forward to reuniting with filmmaker Mohit Suri on the set of their next film, “Ek Villain 2”. The actress has earlier collaborated with Mohit on their 2020 film “Malang”.

Disha will also be seen in “KTina”, produced by Ekta Kapoor. The film also features Akshay Oberoi and Sunny Singh.

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