Placenta changes in older moms not good for male child's heart | WeForNews | Latest News, Blogs Placenta changes in older moms not good for male child’s heart – WeForNews | Latest News, Blogs
Connect with us

Health

Placenta changes in older moms not good for male child’s heart

Published

on

Heart

London: Changes occur in the placenta in mothers over age 35 leading to a greater likelihood of poor health in their male offspring and now, scientists have found in animal studies that placenta changes could put male child of older mothers at heart problems in later life.

Both male and female foetuses do not grow as large in older mothers, but there are sex-specific differences in changes to placental development and function.

These are likely to play a central role in the increased likelihood of later-life heart problems and high blood pressure in males, said the team from the University of Cambridge.

In humans, women over 35 are considered to be of advanced maternal age. The study, published in Scientific Reports, looked at pregnant rats of a comparable age.

“This new understanding of placental development and function could contribute to better management of human pregnancies, and development of targeted interventions to improve the long-term health of children born to older mothers,” said Dr Tina Napso, a postdoctoral fellow at the University of Cambridge and first author of the study.

Pregnancy in older mothers is associated with a heightened risk of complications for both the mother and her baby.

These include preeclampsia – raised blood pressure in the mother during pregnancy, gestational diabetes, stillbirth and foetal growth restriction.

Until now there has been limited understanding of how the placenta is altered by advanced maternal age.

“With the average age of first pregnancy in women becoming higher and higher, and especially so in developed countries, it is very important to understand how the age of the mother and the sex of the baby interact to determine pregnancy and later-life health of the child,” said Dr Amanda Sferruzzi-Perri, lead author of the study.

The placenta transports nutrients and oxygen from mother to foetus, secretes signalling factors into the mother so she supports foetal development, and is the main protective barrier for the foetus against toxins, bacteria, and hormones – such as stress hormones – in the mother’s blood.

It is highly dynamic in nature, and its function can change to help protect the growing fetus when conditions become less favourable for its development, for example through a lack of nutrients or oxygen or when the mother is stressed.

The study found that advanced maternal age reduced the efficiency of the placenta of both male and female foetuses. It affected the structure and function of the placenta more markedly for male fetuses, reducing its ability to support the growth of the fetus.

“A pregnancy at an older age is a costly proposition for the mother, whose body has to decide how nutrients are shared with the foetus. That’s why, overall, foetuses do not grow sufficiently during pregnancy when the mother is older compared to when she is young,” said Dr Napso.

“We now know that growth, as well as gene expression in the placenta is affected in older mothers in a manner that partially depends on sex: changes in the placentas of male fetuses are generally detrimental.”

The research involved collaboration between scientists at the University of Cambridge, the University of Alberta in Canada, the Robinson Research Institute and the University of Adelaide, Australia.

An earlier study performed by the collaborators showed that offspring from mothers who enter pregnancy at an older age have poor heart function and high blood pressure as young adults, and particularly so if they are male.

This new research was conducted to understand why, and whether this sex difference may be due to how the male and female foetuses are supported within the womb in an aged mother.

Although further studies in humans are required, the results suggest the importance of considering the sex of the foetus when giving advice to older pregnant women.

Continue Reading
Advertisement
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

sixteen + seven =

Health

Keto diet may fight against Alzheimer’s disease

Published

on

By

Keto diet-

Washington, Dec 10 : Eating low-carb and high-fat diet can help you fight against Alzheimer’s disease, by protect neurons from death during the progression of Alzheimer’s disease, according to new research in mice.

“Ketogenic” is a term for a low-carb diet (like the Atkins diet). The idea is for you to get more calories from protein and fat and less from carbohydrates. You cut back most on the carbs that are easy to digest, like sugar, soda, pastries and white bread.

Early in the development of Alzheimer’s disease, the brain becomes over excited, potentially through the loss of inhibitory, or GABAergic, interneurons that keep other neurons from signaling too much.

Because interneurons require more energy compared to other neurons, they may be more susceptible to dying when they encounter the Alzheimer’s disease protein amyloid beta.

Amyloid beta has been shown to damage mitochondria – the metabolic engine for cells – by interfering with SIRT3, a protein that preserves mitochondrial functions and protects neurons.

Researchers from the Society for Neuroscience genetically reduced levels of SIRT3 in mouse models of Alzheimer’s disease.

Mice with low levels of SIRT3 experienced a much higher mortality rate, more violent seizures and increased interneuron death compared to the mice from the standard Alzheimer’s disease model and control mice.

However, the mice with reduced levels of SIRT3 experienced fewer seizures and were less likely to die when they ate a diet rich in ketones, a specific type of fatty acid.

The diet also increased levels of SIRT3 in the mice.

“Increasing SIRT3 levels via ketone consumption may be a way to protect interneurons and delay the progression of Alzheimer’s disease,” report researchers.

Continue Reading

Health

New Mediterranean diet lets you eat meat without any guilt

Published

on

Mediterranean diet

Sydney, Dec 9 : Researchers have developed a new version of Mediterranean diet that includes meat to cater to Western tastes and also deliver health benefits.

A typical Mediterranean diet includes extra virgin olive oil, fruits, vegetables, nuts, seeds, legumes, wholegrain breads, pastas and cereals, moderate amount of fish and red wine, and low consumption of red meat, sweet and processed foods.

The new version of the Mediterranean diet includes 2-3 serves (250g) of fresh lean pork each week.

The findings published in the journal Nutrients showed that the Mediterranean-Pork (Med-Pork) diet delivers cognitive benefits.

“The Mediterranean diet is widely accepted as the healthiest diet and is renowned for delivering improved cardiovascular and cognitive health, but in Western cultures, the red meat restrictions of the diet could make it hard for people to stick to,” said Alexandra Wade from University of South Australia.

“By adding pork to the Mediterranean diet, we’re broadening the appeal of the diet, while also delivering improved cognitive function,” Wade said.

This study compared the cognitive effects of people aged 45-80 years and at risk of cardiovascular disease following a Med-Pork or a low-fat diet (often prescribed to negate risk factors for cardiovascular disease).

The results showed the Med-Pork intervention outperformed the low-fat diet, delivering higher cognitive processing speeds and emotional functioning, both markers of good mental health.

“Improving people’s processing speed shows the brain is working well,” Wade said.

“Then, when you add the fact that pork production emits only a fraction of the greenhouse gases compared with beef, and the Med-Pork diet is really ticking all boxes — taste, health and environment,” Wade said.

Continue Reading

Health

Time-restricted eating benefits those at risk for diabetes

Published

on

By

diabetes

New York: Researchers have found that people who are at high risk of developing diabetes improved their health when they consumed all of their meals over a span of just 10 hours, or less over a period of 12 weeks.

The study published in the journal cell Metabolism, reported a form of intermittent fasting, called time-restricted eating, improved the health of study participants who had been diagnosed with metabolic syndrome.

Metabolic syndrome is the name for a group of risk factors, such as high blood pressure and cholesterol levels, that increase the risk for adverse health issues, from heart disease and diabetes to stroke.

The researchers from University of California in US, found that when participants restricted their eating to 10 hours or less over a period of 12 weeks, they lost weight, reduced abdominal fat, lowered blood pressure and cholesterol and enjoyed more stable blood sugar and insulin levels.

“Time-restricted eating is a simple dietary intervention to incorporate, and we found that participants were able to keep the eating schedule,” said study co-author Satchin Panda from the University of California in US.

“Eating and drinking everything (except water) during a 10-hour window allows your body to rest and restore for 14 hours at night. Your body can also anticipate when you will eat, so it can prepare the body to optimize metabolism,” Panda added.

Time-restricted eating (eating all calories within a consistent 10-hour window) allows individuals to eat in a manner that supports their circadian rhythms and their health.

Circadian rhythms are the 24-hour cycles of biological processes that affect nearly every cell in the body.

Erratic eating patterns can disrupt this system and induce symptoms of metabolic syndrome, including increased abdominal fat and abnormal cholesterol or triglycerides.

The study involved 19 participants diagnosed with metabolic syndrome, with 16 taking at least one medication, like a statin.

Participants used an app created by Panda called myCircadianClock to log when and what they ate during an initial two-week baseline period followed by three months of 10-hour time-restricted eating per day.

They were told they could decide what time to eat and how much to eat as long as all food consumption occurred within a 10-hour window.

At the end of the 12 weeks, participants averaged a three per cent reduction in weight and body mass index (BMI) and a four per cent reduction in abdominal/visceral fat.

Many also experienced reductions in cholesterol and blood pressure and improvements in fasting glucose. Seventy percent of participants reported an increase in sleep satisfaction or in the amount they slept.

“Patients also reported that they generally had more energy, and some were able to have their medications lowered or stopped after completing the study,” said study researcher Pam Taub from University of California.


Continue Reading
Advertisement

Most Popular