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Paracetamol in pregnancy may damage your daughter’s fertility

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pregnancy medicine

London, Jan 7: Women who consume paracetamol during pregnancy, widely used to reduce a high fever or relieve pain, may increase the risk of damaging the fertility of their daughters, warns a new study.

Scientists from the University of Edinburgh in Scotland found that human ovaries exposed to paracetamol for a week in laboratories lost up to 40 per cent of their egg cells.

If this effect occurs in the womb, it could mean baby girls exposed to the common drug end up being born with fewer eggs. This would give them fewer years in which they could become pregnant and lead to an early menopause, the Daily Mail quoted the researchers as saying.

It may be because both paracetamol and ibuprofen interferes with a hormone called prostaglandin E2, which appears to play a vital part in the development of the foetal reproductive system.

“This study identifies a potential risk from taking paracetamol or ibuprofen, although we don’t know exactly what effect it would have on human health nor what dose would be needed to harm fertility,” said Richard Sharpe, professor at the varsity.

While unborn boys could also be affected by the drug. But unlike women, whose egg supply is limited, they keep producing sperm throughout their lives, meaning the danger to their fertility is not as serious, the researchers said.

For the study, presented at the Fertility 2018 conference in Liverpool, the team tested the effect of paracetamol and ibuprofen on human foetal testes and ovaries over a week. Researchers counted germ cells that turn into sperm and eggs.

In the ovary, the number of egg cells fell by up to 40 per cent, while in testes the number of germ cells was reduced by more than a fifth.

The findings prompts fresh warnings for pregnant women to only take paracetamol when necessary and warrants further research.

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Health

High Vitamin D levels may reduce breast cancer risk

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vitamin D

New York, June 16: Higher levels of Vitamin D among women may reduce their risk of developing breast cancer post menopause, claimed a new study.

The study found that women with blood levels of serum 25-hydroxyvitamin D (OH) — the main form of vitamin D in blood — above 60 ng/ml (nanograms per millilitre) had one-fifth the risk of breast cancer compared to those with less than 20 ng/ml.

Thus, researchers from the University of California-San Diego determined that the minimum healthy level of 25(OH) in blood plasma should be 60 ng/ml, instead of the earlier recommended higher than the 20 ng/ml.

“Increasing Vitamin D blood levels substantially above 20 ng/ml appears to be important for the prevention of breast cancer,” said lead author Sharon McDonnell from GrassrootsHealth, a non-profit public health research organisation.

The study, published in the journal PLOS ONE, analysed data from two randomised clinical trials with 3,325 combined women and a prospective study involving 1,713 women with average age of 63.

Participants were free of cancer at enrollment and were followed for a mean period of four years. Vitamin D levels in blood were measured during study visits.

“This study was limited to postmenopausal breast cancer. Further research is needed on whether high 25(OH)D levels might prevent premenopausal breast cancer,” said Cedric F. Garland from UC-San Diego.

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Congenital Heart Disease Often Lead To Mental Illness

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WORLD HEART DAY

More than 1.5 lac infants are born in India annually with congenital heart disease. Around 78,000 infants die of congenital heart disease in India every year.

So What Is Congenital Heart Disease?

Congenital Heart Disease (CHD) is when a child is born with an abnormality in his/her heart. It could be abnormal in the way it’s structured (have parts of the organ missing, have functional problems and/or holes in the chambers. Doctors are often able to diagnose CHD while the child is still in the womb of the mother. CHD is considered to be a life threatening illness and hence can cause emotional turmoil in parents of the child, which in turn affects the psychological development of the unborn child.

Additional alterations immediately after birth for a child can prove to be traumatic, and cause PTSD like symptoms later on in life. For example, a child is often separated from the child’s mother and placed in intensive care immediately after birth, and then they are subjected to invasive medical procedures and tests. An infant with CHD goes through a traumatic event which is often reflected in feeding problems, nightmares and over all behavior of the infant.

According to Dr.Vihan Sanyal, psychotherapist, “Parents of children with CHD can seek the help of a skilled psychotherapist for their children’s psychological health while they are children. This will give the therapist to address the issue early on and help improve the quality of life of the child well into adulthood”

Early stressful experiences of a child can alter the child’s brain development, affect their immune system (the child tends to fall sick more often) and disturb the way a child reacts to stressful events in future life. Studies have proven that children who have been exposed to highly stressful environments early on in childhood often have issues with cognition and in processing of emotions.

Neonatal care, pediatric care, adolescent years and adulthood of a person diagnosed with CHD is often complex and challenging for the person. The psychological impact this creates is profound and can lead to suicide in adulthood if not managed properly.

Dr.Sanyal explains: “Children with CHD have difficulties with motor skills, speech, focus & attention, executive functioning, impulse control, management of emotions and behavior. The change in the structure of the brain and in brain chemistry can tarnish the image a child has of himself. He can quickly form an opinion of himself as being “abnormal”, leading to self esteem issues. It is important for children to be helped by a skilled psychotherapist, who is proficient in dealing with psychological issues of children living with CHD. Timely therapeutic intervention can provide the support a child requires in coping with the emotional challenges of CHD.”

Psychiatric disorders, in particular mood and anxiety disorders are more frequent in Adults with CHD compared to Non-CHD adults.

Life threat to the fetus is an important key factor for emotional disturbance during pregnancy for the parents. It is also an indication of long term psychological disorders faced by the parents of the child with CHD.

Studies have indicated that more than 30% of parents with children who have been diagnosed with CHD show signs of Post Traumatic Stress Disorder (PTSD). 50% of them have shown to have anxiety and depression. More than 80% of these parents have tested positive for psychological stress related disorders.

“MNLP & other modalities of psychotherapy can help the parents of those who have recently been diagnosed with CHD. MNLP can help in building resilience in the parents and equip them to face the challenges which lay ahead without disintegrating emotionally. Hypnotherapy can be used to promote relaxation and to address issues of trauma in the subconscious” Say’s Dr.Sanyal

Contributory Factors While Pregnant Which Can Result In CHD

· Smoking during pregnancy

· Consuming alcohol during pregnancy

· Exposure To Poor Air Quality (pollution)

· Exposure to Toxic Chemicals (Even common household chemicals like toilet cleaners and detergents)

· Exposure to pesticides and insecticides

· Medicines not meant to be consumed during pregnancy

· Obesity in mothers

In addition to the above list, symptoms of anxiety and depression in pregnant women often go undetected and hence, remain untreated. It is also important to mention that a range of symptoms of stress, anxiety and depression, marital harmony and quality of relationship the parents share with each other all have an effect on the fetus’s psychological health.

Dr.Sanyal says: “Many pregnant women of our country are unaware of some of the precautions they need to take during pregnancy. More importantly, they are unaware of the harmful effects the unborn child could face due to their habit and behavior. Many psychological disorders and mental illnesses can be prevented by pregnant women choosing to lead a balanced and a relatively stress free life during their pregnancy.”

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Can sleeping more affect your heart?

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world sleep day

Seoul, June 13: If you thought that only less hours of sleep would affect your health, then you are wrong. Sleeping more than 10 hours per day is also associated with metabolic syndrome, raising the risk for heart diseases, according to a new study.

Those who slept for over 10 hours daily were at risk of elevated waist circumference, high triglyceride levels — a type of fat, low levels of “good” cholesterol, hypertension as well as high fasting blood sugar — referred to as metabolic syndrome and associated with increased risk of cardiovascular diseases.

While sleeping more raised triglycerides levels in both men and women, in women it led to higher waist circumference, blood sugar as well as lower levels of “good” cholesterol.

Conversely, getting less than six hours of sleep was associated with higher risk of metabolic syndrome in men and higher waist circumference among both men and women, researchers said.

“This is the largest study examining a dose-response association between sleep duration and metabolic syndrome and its components separately for men and women,” said lead author Claire E. Kim from Seoul National University College of Medicine in South Korea.

The study, published in the journal BMC Public Health, included data from 1,33,608 participants aged between 40-69 years. The results showed that the prevalence of metabolic syndrome was just over 29 per cent in men and 24.5 per cent in women.

“We observed a potential gender difference between sleep duration and metabolic syndrome, with an association between metabolic syndrome and long sleep in women and metabolic syndrome and short sleep in men,” said Kim.

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