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Pancreatic cancer survival linked to four genes: Study

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Pancreatic cancer

New York, Nov 5: Researchers have found that alterations in four main genes are responsible for how long patients survive with pancreatic cancer.

“The research helps us to understand how the molecular features of pancreatic cancer impact prognosis on an individual level and gives us more facts to guide patients, and importantly, to design future research studies,” said study co-author Aram Hezel, Medical Oncology at University of Rochester.

For the study, published in the Journal JAMA Oncology, involved 356 patients who all had pancreatic adenocarcinoma that could be surgically removed.

Adenocarcinoma is by far the most common type of pancreas tumour.

Ninety of the patients were treated at the University of Rochester Medical Centre’s Wilmot Cancer Institute; the others at Dana Farber/Brigham and Women’s Cancer Centre in Boston and Stanford Cancer Institute.

In all cases after the tumours were removed, scientists extracted DNA from the cancerous tissue and nearby normal tissue and conducted next-generation DNA sequencing on the specimens.

The analysis centred on the activity of the KRAS, CDKN2A, SMAD4, and TP53 genes.

Results showed that patients who had three or four of the altered genes had worse disease-free survival (the time between surgery and when the cancer returns), and overall survival (from surgery to death), compared to patients with a single or two altered genes.

Pancreatic cancer is aggressive and generally has poor survival odds.

“Patients who can undergo surgery as part of treatment often survive longer and some patients fare best when they can receive chemotherapy prior to surgery. But having customised, molecular information will provide an even greater understanding of how the disease is likely to progress in each patient,” Hezel noted.

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Ebola death toll rises to 200 in Congo

The DRC authorities declared the outbreak in North Kivu province on August 1. It was also reported in the northern province of Ituri.

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Ebola Infection

Kinshasa, Oct 21 : The death toll in the Ebola outbreak in the Democratic Republic of Congo (DRC) has risen to 200, the Health Ministry has said.

According to statistics released by the Ministry on Saturday, of the 200 cases confirmed in Beni and surrounding areas, 117 have died of the virus while 61 others recovered after treatment, Xinhua news agency reported.

The DRC authorities declared the outbreak in North Kivu province on August 1. It was also reported in the northern province of Ituri.

The World Health Organization said the 10th Ebola outbreak in DRC does not currently constitute a public health emergency of international concern.

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Cycling, walking in nature may improve your mental health

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London, Oct 20: People who commute — walking or cycling — through natural environments are more likely to develop better mental health than those who commute less, according to a new study.

Natural environments included all public and private outdoor spaces that contain ‘green’ and/or ‘blue’ natural elements such as street trees, forests, city parks and natural parks/reserves and all types of water bodies.

“Mental health and physical inactivity are two of the main public health problems associated with the life in urban environments. Urban design could be a powerful tool to confront these challenges and create healthier cities. One way of doing so would be investing in natural commuting routes for cycling and walking,” said Mark Nieuwenhuijsen from the University of Barcelona.

For the study, published in the journal, Environment International, the research team examined nearly 3,600 participants who answered a questionnaire about their commuting habits and their mental health.

The findings showed that respondents commuting through natural environments on a daily basis had on average a 2.74 point higher mental health score compared to those who commuted through natural environments less frequently.

This association was even stronger among people who reported active commuting, the team said.

“From previous experimental studies we knew that physical activity in natural environments can reduce stress, improve mood and mental restoration when compared to the equivalent activity in urban environments,” said first author Wilma Zijlema from the varsity.

“Although this study is the first of its kind to our knowledge and, therefore, more research will be needed, our data show that commuting through these natural spaces alone may also have a positive effect on mental health.”

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Number of Zika virus cases reaches 100 in Jaipur

A total of 1,11,825 houses have been screened. Special precautions are being taken in the Zika-affected areas.

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Zika virus

Jaipur, Oct 18 : The number of people infected with the Zika virus has gone up to 100 in Jaipur, officials said on Thursday.

State Chief Secretary D.B. Gupta held a review meeting and directed the officials to carry out anti-larvae activities in educational institutions and administrative buildings in Jaipur.

Veenu Gupta, Chief Secretary (Medicine and Health) said, “Medical teams in Jaipur are carrying out screening and fogging activities. A total of 1,11,825 houses have been screened. Special precautions are being taken in the Zika-affected areas.”

She said that there was no shortage of medicines at health centres. She also directed district officials to monitor the regular availability of medicines and testing equipment in hospitals.

Gupta directed officials to take measures to prevent breeding of mosquitoes in the Rajasthan Police Academy, Police Line and the RAC Battalion.

She asked the Army officials to check the spread of mosquitoes and larvae in their area.

Gupta instructed officials to pay special attention to tourist places such as Hawa Mahal, Jantar Mantar and Albert Hall.

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