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Oral capsule to deliver insulin that has to be injected

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Insulin

Washington, Oct 9 (IANS) Scientists in the US have designed an oral drug capsule that can carry insulin and protect it from the harsh environment in the digestive tracts.

The study published in this week’s Nature Medicine has shown that the capsule containing proteins that cannot be taken orally reaches the small intestine before breaking down to release dissolvable tiny needles, the Xinhua news agency reported.

Those needles then attach to the intestinal wall and release drug for fast uptake into the bloodstream, according to the study.

In tests in pigs, researchers from Massachusetts Institute of Technology (MIT) showed that this capsule could load a comparable amount of insulin to that of an injection.

Earlier this year, they developed a blueberry-sized capsule containing a small needle made of compressed insulin. Upon reaching the stomach, the needle injects the drug into the stomach lining. In the new study, the researchers developed a capsule that could inject its contents into the wall of the small intestine.

They coated the 30-millimeter-long capsule with a polymer that can survive the acidic environment of the stomach. The capsule breaks open in the small intestine as the pH is higher, and then springs three folded arms containing patches of one-millimeter-long needles that can carry insulin, according to the study.

When the arms unfold open, the force of their release allows the needles to just penetrate the topmost layer of the small intestine tissue. After insertion, the needles dissolve and release the drug.

Also, the arms would break apart after the needle patches are applied to reduce the risk of blockage in the intestine.

“We can deliver insulin, but we see applications for many other therapeutics and possibly vaccines,” said Giovanni Traverso at MIT.

Health

After Gowda episode, Karnataka exempts ministers, officials from quarantine

Gowda, a Lok Sabha member from the Bangalore North constituency, flew into the city in a commercial flight on the first day of resumption of domestic services after 63 days of lockdown.

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Sadananda Gowd

Bengaluru, May 25 : The Karnataka government exempted Union and state ministers and officials from quarantine, which it made mandatory for all entering the state from other states or overseas to contain the Covid-19 outbreak, a top official said on Monday.

“The ministers of Union government or state governments or officers on duty will be exempted from quarantine as has been done for health professionals,” said state Health Commissioner P.K. Pandey in an order here.

The order has also exempted any person who gets a Covid negative test certificate from an ICMR approved lab which is not more than 2 days old from the date of journey, from institution quarantine.

The order has also exempted airlines crew on official duty from quarantine.

The order came on a day when Union Minister for Chemicals and Fertilisers D.V. Sadananda Gowda was allowed to exit the airport on arriving from New Delhi without going into 7-day institutional quarantine, as other passengers who too came from the national capital, which is one of the 6 most Covid-hit states in the country.

Gowda, a Lok Sabha member from the Bangalore North constituency, flew into the city in a commercial flight on the first day of resumption of domestic services after 63 days of lockdown.

“I am exempted under the clause by the state government as well as the Central government,” Gowda told a local news channel when asked how he could avoid the mandatory quarantine on landing from Delhi.

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Health

Domestic passengers landing at Kerala don’t seem to need Aarogya Setu

After landing at the airport here, all were asked to pass through a thermal scanner.

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Pinarayi Vijayan

Thiruvananthapuram, May 25 : With the commercial domestic aviation services restarting in the country on Monday, it appears the Aarogya Setu app is not a requirement at the Thiruvananthapuram airport.

A passenger who arrived from Delhi on the first flight that landed here on Monday told IANS that no one asked him about Aarogya Setu app inside or outside the airport here.

“When I entered the Delhi airport, I was asked if I have Aarogya Setu app and I said yes. Then I was allowed to enter the airport. In the aircraft what I could see was social distancing was maintained. There was no in-flight service of any sort during the flight,” said the passenger who did not wished to be identified.

After landing at the airport here, all were asked to pass through a thermal scanner.

“After that there is a health desk with a doctor and a few others. They asked me a few questions and I was let off as I had no symptoms. Then I had to fill a few forms and then went to a counter where I showed the pass that I had received when I first registered online two days back, before I booked my air ticket. The person manning the counter asked me all my details of where I will be staying and such things. After the registration was over, I got another pass and was allowed to go out of the airport,” said the passenger and added no one asked him about the app.

“Outside I could see buses of the state-owned Transport Department and I took a car and reached my home, where I have been asked to be in quarantine for 14 days. Now I will be staying indoors till my quarantine period is over,” added the passenger who works in Delhi.

According to rules here, anyone arriving in Kerala on flights, can go into state run quarantine centres, if they so wish or if they have a separate attached bathroom at their home can remain in it for two weeks, when the quarantine period will end.

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Cities

163 new COVID19 cases in Bihar, tally 2,737

Death toll in the state is 13, with Patna, Vaishali and Khagaria accounting for two fatalities each and one death reported from Munger, Rohtas, Begusarai, East Champaran, Sitamarhi, Siwan and Saran districts each.

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Corona outbreak PPE Kits

Patna, May 25 : With 163 fresh cases on Monday, the COVID-19 tally stood at 2,737 in Bihar, where the number of infection has seen a rapid rise in the recent past mainly on the account of the influx of migrant workers, the health department said.

The department put the number of migrants testing positive since May 3 at 1,754, which is close to 80 per cent of the total number of cases reported during the period. Special trains carrying them from far and wide began reaching the state on May 2.

The majority of the infected migrants are returnees from Delhi (411), Maharashtra (403), Gujarat (276), Haryana (146), Rajasthan (95), Uttar Pradesh (89), Telangana (81) and West Bengal (76), according to a break-up provided by the department.

Among the 163 cases reported during the day, Patna district accounted for 11, which caused its tally to reach 211. Two of these were reported from Lodipur and Samanpura localities of the state capital, while the remaining were from rural areas of the district, the worst-hit in Bihar.Advertisement
Bihar had reported 180 new cases of COVID-19 from 15 districts on Sunday.

Cases have been reported from all 38 districts of the state and nine of these — Patna, Rohtas, Begusarai, Munger, Madhubani, Katihar, Khagaria, Buxar and Jehanabad — have tallies in three-digits. Only Sheohar has reported less than 10 cases.

Death toll in the state is 13, with Patna, Vaishali and Khagaria accounting for two fatalities each and one death reported from Munger, Rohtas, Begusarai, East Champaran, Sitamarhi, Siwan and Saran districts each.

The number of samples tested so far is 66,148.

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