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Omega 3 fatty acid found to stop liver damage from getting worse

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San Francisco, April 20: A new study done with laboratory animals suggests that one type of omega 3 fatty acid offers people, who are obese or have a poor diet, a chance to avoid serious liver damage.

The findings, published on Wednesday by researchers from Oregon State University (OSU) in PLOS ONE, offer something that no available drug can accomplish, as millions of people in the developed world try, and fail, to sustain weight loss or eat an optimal diet.

Supplements of docosahexaenoic acid (DHA), one of the most critically important of the omega 3 fatty acids, were shown to stop the progression of nonalcoholic steatohepatitis (NASH), into more serious and life-threatening health problems such as cirrhosis or liver cancer, Xinhua news agency reported.

Characterised by liver inflammation, oxidative stress and fibrosis, NASH is a substantial risk factor for cirrhosis and liver cancer.

It is predicted to be the leading cause of liver transplants by 2020, and the US Food and Drug Administration (FDA) currently has no approved medical treatments for it.

Based in large part on consuming the “western diet,” one that is high in fat, sugar and cholesterol, nearly 80 million adults and 13 million children in the United States are obese, and about 30 percent of the nation’s population is estimated to have some form of chronic fatty liver disease.

“Considering there are no FDA-approved ways to stop NASH progression, other than weight loss therapy, this supplement may be of significant help,” said Donald Jump, a professor in the OSU College of Public Health and Human Sciences, and principal investigator with the Linus Pauling Institute.

“In the time frame that we studied, DHA supplementation was not able to achieve full remission of NASH, but it did stop it from getting worse,” Donald Jump said.

And it took place even with the continued consumption in lab animals of a “western diet.”

Over one 10-year study period, cirrhosis and liver-related deaths occurred in 20 per cent and 12 per cent of NASH patients, respectively. And when humans with NASH are examined, they have very low levels of omega 3 fatty acids. When those levels are raised, the disease progression stops.

Omega 3 fatty acids regulate important biological pathways, including fatty acid synthesis, oxidation, and breakdown of triglycerides, or fats in the blood. DHA appears to be one of the most significant of the omega 3 fatty acids, and plays a role in repairing liver damage.

The highest levels of DHA are found in oily fish such as salmon, mackerel, tuna and sardines, and to a much lesser extent in some foods such as poultry, liver, egg yolks, and some types of algae.

It is increasingly being included in some prenatal vitamin and mineral formulas because of studies showing its critical importance to a developing fetus.

DHA is a readily available supplement and safe to use. Referring to the use of DHA supplementation to address problems with NASH, the researchers said in their study that “this scenario.

IANS

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Maternal blood sugar likely to affect baby’s heart

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New York, Dec 16: Women with high blood sugar early in pregnancy may raise their baby’s risk of developing a congenital heart defect, according to a study.

While it has been long known that diabetes in pregnancy raises the odds for congenital heart defects in babies.

The new findings reveal that risk extends even to women without diabetes in their earliest part of pregnancy, when the foetal heart is forming.

“Most women who have a child with congenital heart disease are not diabetic,” said James Priest, assistant professor at the Stanford University in California.

The results showed that the risk of giving birth to a child with a congenital heart defect was elevated by 8 per cent for every increase of 10 milligrams per deciliter in blood glucose levels in the early stages of pregnancy.

“We found that in women who don’t already have diabetes or develop diabetes during pregnancy, we can still measure risk for having a child with congenital heart disease by looking at their glucose values during the first trimester of pregnancy,” Priest added.

For the study, published in The Journal of Paediatrics, the team examined medical records from 19,107 pairs of mothers and their babies born between 2009 and 2015, which included details of the mothers’ prenatal care, including blood test results and any cardiac diagnoses made for the babies during pregnancy or after birth.

The study may be helpful to measure blood glucose early in pregnancy in all pregnant women to help determine which individuals are at greater risk for having a baby with a heart defect.

“Knowing about defects prenatally improves outcomes because mothers can receive specialised care that increases their babies’ chances of being healthier after birth,” Priest added.

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Radiation from smartphones may up miscarriage risk: Study

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New York, Dec 14: Pregnant women’s exposure to non-ionising radiation from smartphones, Bluetooth devices and laptops may more than double the risk of miscarriage, a study has showed.

Non-ionising radiation — radiation that produces enough energy to move around atoms in a molecule, but not enough to remove electrons completely — from magnetic fields is produced when electric devices are in use and electricity is flowing.

It can be generated by a number of environmental sources, including electric appliances, power lines and transformers, wireless devices and wireless networks.

While the health hazards from ionising radiation are well-established and include radiation sickness, cancer and genetic damage, the evidence of health risks to humans from non-ionising radiation remains limited, said De-Kun Li, a reproductive and perinatal epidemiologist at the Kaiser Permanente — a US-based health care firm.

For the study, published in the journal Scientific Reports, the team asked for 913 pregnant women over age 18 to wear a small (a bit larger than a deck of cards) magnetic-field monitoring device for 24 hours.

After controlling for multiple other factors, women who were exposed to higher magnetic fields levels had 2.72 times the risk of miscarriage than those with lower magnetic fields exposure.

The increased risk of miscarriage associated with high magnetic fields was consistently observed regardless of the sources of high magnetic fields. The association was much stronger if magnetic fields was measured on a typical day of participants’ pregnancies.

The finding also demonstrated that accurate measurement of magnetic field exposure is vital for examining magnetic field health effects.

“This study provides evidence from a human population that magnetic field non-ionising radiation could have adverse biological impacts on human health,” Li noted.

“We hope that the finding from this study will stimulate much-needed additional studies into the potential environmental hazards to human health, including the health of pregnant women,” he said.

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Use of Smartphone before sleep may make your kid obese: Study

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New York, Dec 10: Beware if your children have a habit of playing games on smartphones before sleeping, he or she may face an increased risk of becoming obese, warns a study.

It was discovered kids who used digital devices such as watching TV or playing games on smartphones before going to bed got an average of 30 minutes less sleep in comparison to those who did not.

This lack of proper sleep not only caused fatigue and attention problems in school, but also disrupted their eating habits. This leads to higher body mass indexes (BMI), news agency IANS reported.

“We saw technology before bed being associated with less sleep and higher BMIs,”stated Caitlyn Fuller, researcher at the Pennsylvania State University in the US.

“We also saw this technology use being associated with more fatigue in the morning, which circling back, is another risk factor for higher BMIs. So we’re seeing a loop pattern forming,” Fuller further asserted.

The study, published in the journal Global Pediatric Health, examined the sleep and technology habits of 234 children, between the age of eight to 17 years.

As per the suggestions from the American Academy of Pediatrics (AAP), parents should set some limitations regarding the use of technology, like requiring their kids to put away their devices during meal times and keeping phones out of bedrooms at night.

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