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Omega 3 fatty acid found to stop liver damage from getting worse

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liver

San Francisco, April 20: A new study done with laboratory animals suggests that one type of omega 3 fatty acid offers people, who are obese or have a poor diet, a chance to avoid serious liver damage.

The findings, published on Wednesday by researchers from Oregon State University (OSU) in PLOS ONE, offer something that no available drug can accomplish, as millions of people in the developed world try, and fail, to sustain weight loss or eat an optimal diet.

Supplements of docosahexaenoic acid (DHA), one of the most critically important of the omega 3 fatty acids, were shown to stop the progression of nonalcoholic steatohepatitis (NASH), into more serious and life-threatening health problems such as cirrhosis or liver cancer, Xinhua news agency reported.

Characterised by liver inflammation, oxidative stress and fibrosis, NASH is a substantial risk factor for cirrhosis and liver cancer.

It is predicted to be the leading cause of liver transplants by 2020, and the US Food and Drug Administration (FDA) currently has no approved medical treatments for it.

Based in large part on consuming the “western diet,” one that is high in fat, sugar and cholesterol, nearly 80 million adults and 13 million children in the United States are obese, and about 30 percent of the nation’s population is estimated to have some form of chronic fatty liver disease.

“Considering there are no FDA-approved ways to stop NASH progression, other than weight loss therapy, this supplement may be of significant help,” said Donald Jump, a professor in the OSU College of Public Health and Human Sciences, and principal investigator with the Linus Pauling Institute.

“In the time frame that we studied, DHA supplementation was not able to achieve full remission of NASH, but it did stop it from getting worse,” Donald Jump said.

And it took place even with the continued consumption in lab animals of a “western diet.”

Over one 10-year study period, cirrhosis and liver-related deaths occurred in 20 per cent and 12 per cent of NASH patients, respectively. And when humans with NASH are examined, they have very low levels of omega 3 fatty acids. When those levels are raised, the disease progression stops.

Omega 3 fatty acids regulate important biological pathways, including fatty acid synthesis, oxidation, and breakdown of triglycerides, or fats in the blood. DHA appears to be one of the most significant of the omega 3 fatty acids, and plays a role in repairing liver damage.

The highest levels of DHA are found in oily fish such as salmon, mackerel, tuna and sardines, and to a much lesser extent in some foods such as poultry, liver, egg yolks, and some types of algae.

It is increasingly being included in some prenatal vitamin and mineral formulas because of studies showing its critical importance to a developing fetus.

DHA is a readily available supplement and safe to use. Referring to the use of DHA supplementation to address problems with NASH, the researchers said in their study that “this scenario.

IANS

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Health

Can drinking too much water harm you?

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Water

Toronto, May 23: Do you drink too much water? Beware, overhydration — excess fluid accumulation — can lead to dangerously low sodium levels or in the blood or result in brain swelling, researchers say.

Hyponatremia, a life-threatening condition of brain swelling, is more common in elderly patients and can cause cognitive problems and seizures.

“(Hyponatremia) occurs in common pathological conditions, including brain injury, sepsis, cardiac failure and in the use of drugs, such as MDMA (ecstasy),” said Charles Bourque from the McGill University in Canada.

While it was yet uncertain how hyponatremia develops, the study found that a defect in the hydration sensing mechanism of the brain could be the culprit.

The researchers said that brain’s hydration sensing neurons could not detect overhydration in the same way that they detect dehydration.

Overhydration activates Trpv4 — a calcium channel that can be found in glial cells, that act to surround hydration sensing neurons.

It is cellular gatekeeper implicated in maintaining the balance of water in the body.

“Our study shows that it is in fact glial cells that first detect the overhydrated state and then transfer this information to turn off the electrical activity of the [hydration sensing] neurons,” Bourque explained.

“Our specific data will be important for people studying hydromineral and fluid electrolyte homeostasis, and clinicians who treat patients faced with hyponatremia,” he noted.

The results, published in the journal Cell Reports, showed that overhydration is first identified by the Trpv4 channel which triggers the release of a type of amino acid known, taurine, which acts as a trip wire to inhibit hydration sensing neurons.

“Preclinical models of hyponatremia will be used to examine if the mechanism we report is affected in this condition with the long-term objective of designing new treatments or diagnostic tools,” Bourque added.

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An egg a day may keep heart diseases away

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Beijing, May 22: If you thought eating eggs is bad for your heart due to their high cholesterol content, think again. A large study has now shown that people who consume an egg every day could significantly reduce their risk of cardiovascular diseases.

“The present study finds that there is an association between moderate level of egg consumption (up to one egg/day) and a lower cardiac event rate,” the study authors said.

The researchers pointed out that eggs are a prominent source of dietary cholesterol, but they also contain high-quality protein, many vitamins and bioactive components such as phospholipids and carotenoids.

Cardiovascular disease (CVD) is the leading cause of death and disability worldwide mostly due to ischaemic heart disease and stroke (including both haemorrhagic and ischaemic stroke).

For the study, published in the journal Heart, Chenxi Qin from Peking University Health Science Centre in Beijing, and colleagues set out to examine the associations between egg consumption and cardiovascular disease, ischaemic heart disease, major coronary events, haemorrhagic stroke and ischaemic stroke.

They used data from the China Kadoorie Biobank (CKB) study, an ongoing prospective study of around half a million (512,891) adults aged 30 to 79 from 10 different geographical areas in China.

The researchers focused on 416,213 participants who were free of prior cancer, cardiovascular disease (CVD) and diabetes.

Analysis of the results showed that compared with people not consuming eggs, daily egg consumption was associated with a lower risk of CVD overall.

In particular, daily egg consumers (up to one egg per day) had a 26 per cent lower risk of haemorrhagic stroke, a 28 per cent lower risk of haemorrhagic stroke death and an 18 per cent lower risk of CVD death.

In addition, there was a 12 per cent reduction in risk of ischaemic heart disease observed for people consuming eggs daily, when compared with the ‘never/rarely’ consumption category — about 2.03 eggs per week.

This was an observational study, so no firm conclusions can be drawn about cause and effect, but the authors said their study had a large sample size and took into account established and potential risk factors for CVD.

IANS

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Delhi govt planning free dialysis at pvt hospitals: Jain

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Dialysis

New Delhi, May 21 : The Delhi government is planning to make the dialysis procedure free at private hospitals and dialysis centres on a public-private-partnership basis, subject to conditions, Health Minister Satyendar Jain said today.

Jain said only those private hospitals and standalone centres which have more than 10 dialysis machines and are empanelled under the Delhi Government Employees Health Scheme or the Central Government Health Scheme would be eligible to become a partner in the project.

Delhi government through the Delhi Arogya Kosh will pay them Rs 1,274 per dialysis.

Delhi residents who have been living in the city for the past three years and having an annual income of less than Rs 3 lakh shall be eligible to avail the facility, Jain said.

The government is also installing dialysis machines at its own hospitals.

“We have installed 15 machines out of the 75 machines that we intend to install at various hospitals,” he said.

Jain said the idea behind providing the facility at private hospitals or dialysis centres is to cut the travel time for patients, who otherwise may have to go long distance to avail that facility at a government hospital.

“This would be like a reverse referral facility where patients would be referred to an empanelled hospital or centre nearby their home,” he said.

Jain said the government was in an “expansion mode” as far as health services were concerned.

“Five of our hospitals have already earned NABH entry-level accreditation – Pt Madan Mohan Malviya Hospital, Shri Dada Dev Matri Avum Shishu Chikitsalaya, Acharya Shree Bhikshu Hospital, Guru Gobind Singh Hospital and Dr Baba Saheb Ambedkar Hospital,” he said.

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