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Not believing in act of God, Covid vaccine expected in early 2021: Harsh Vardhan

In his over half-an hour address, Harsh Vardhan lauded the effort of various corona warriors, as he said, “We are fighting this war with the help of lakhs of corona warriors”.

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Harsh Vardhan

New Delhi, Sep 22 : Union Health Minister Harsh Vardhan assured the Lok Sabha that the Central government is not just waiting for “act of God” in fight against Covid-19 but also working round-the-clock in the direction to get solution and a vaccine will be available in the beginning of the next year anytime.

The Minister’s assurance came on Monday when he was speaking in the lower House in a late night discussion of the passage of the Epidemic Diseases (Amendment) Bill, 2020 which seeks amendment to the Epidemic Diseases Act, 1897 and will replace the Epidemic Diseases (Amendment) ordinance, 2020 which was promulgated by the President on April 22.

Harsh Vardhan’s response came in a reply to a Member of Parliament who alleged that the government is waiting for the act of God in fight against the disease which on Monday inched closer to 55 lakh-mark in India with a total of 54,87,580 cases in 235 days since the first case was reported on January 30.

In his over half-an hour address, Harsh Vardhan lauded the effort of various corona warriors, as he said, “We are fighting this war with the help of lakhs of corona warriors”.

Pressing the Bill for its passage in order to provide protection to healthcare service personnel, their living premises as well as their workplaces against any violence during the course of a pandemic, the Minister mentioned how the health workers were attacked in many incidents while their service to the infected Covid patients.

As the Parliament was not in session, the Minister said the government came with an ordinance to protect such attacks on corona warriors, and mentioned that the act is to empower the state governments.

“If any person attacks a corona warrior he will be penalised as per the legal provisions. A special officer will investigate the case and submit a report within a month,” the Minister said.

Fight against corona is a battle of 135 crore people, said Harsh Vardhan, adiding all governments fought with the disease unitedly. He also urged Members of Parliament (MPs) not to have any kind of discrepancies on the issue and support in passing the Bill, which was passed by the Rajya Sabha on Saturday.

The Bill seeks to bring a law that punishes those who attack health workers or doctors who are fighting the coronavirus outbreak or during any situation similar to the current Covid-19 pandemic. The draft legislation provides for up to five years in jail for those who attack doctors and health care personnel.

Penalty ranging from Rs 50,000 to Rs 2,00,000 can be slapped on any individual who is involved in commission or abetment of such acts of violence. It can also be punishable in the form of an imprisonment for a term of three months to five years.

Disaster

Sanofi, GSK to supply COVAX with 200 mn doses of COVID-19 vaccine

Translate Bio has established mRNA manufacturing capacity and Sanofi expects to be able to supply annual capacity of 90 to 360 million doses.

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COVID-19 Vaccine

New Delhi, Oct 29 : Sanofi and GSK have signed a Statement of Intent with Gavi, the legal administrator of the COVAX Facility, a global risk-sharing mechanism for pooled procurement and equitable distribution of eventual COVID-19 vaccines.

Sanofi and GSK intend to make available 200 million doses of their adjuvanted recombinant protein-based COVID-19 vaccine, if approved by regulatory authorities and subject to contract, to the COVAX Facility.

Both Companies intend to contribute to COVAX’s ambition to ensure successful COVID-19 vaccines reach those in need, whoever they are and wherever they live, once they obtain appropriate approvals.

“To address a global health crisis of this magnitude, it takes unique partnerships. The commitment we are announcing today for the COVAX Facility can help us together stand a better chance of bringing the pandemic under control,” said Thomas Triomphe, Executive Vice President and Global Head of Sanofi Pasteur.

“This moment also reflects our long-term commitment to global health and ensures our COVID-19 vaccines are affordable and accessible to those most at risk, everywhere in the world.”

Roger Connor, President of GSK Vaccines added, “Since we started working on the development of COVID-19 vaccines, GSK has pledged to make them available to people around the world. We are proud to be working with Sanofi to make this adjuvanted recombinant protein-based vaccine available to the countries signed up to the COVAX Facility as soon as possible – this has the potential to be a significant contribution to the global fight against COVID-19.”

The COVAX Facility is part of COVAX, a global collaboration of governments, global health organisations, businesses and philanthropic organisations working to accelerate development, production, and equitable access to COVID-19 vaccines. COVAX is co-led by Gavi, the Coalition for Epidemic Preparedness Innovations (CEPI) and WHO and forms the vaccines pillar of the Access to COVID-19 Tools (ACT) Accelerator. More than 180 countries and economies have signed onto the COVAX Facility to get timely and cost-effective access to vaccines to meet the global scale of the COVID-19 pandemic.

Through the COVAX Facility’s efforts, vaccines will be distributed in participating countries through the WHO’s recently published Allocation Framework, and the WHO’s Strategic Advisory Group of Experts on Immunization (SAGE) Values Framework which has begun to frame future guidance on vaccine use. These allocation principles aim to ensure that people in all parts of the world will get access to COVID-19 vaccines once they are available.

Sanofi and GSK initiated a Phase 1/2 study on September 3 with a total of 440 subjects enrolled, and anticipate first results in early December 2020, to support the initiation of a pivotal Phase 3 study before the end of the year. If these data are sufficient for licensure application, it is planned to request regulatory approval from the first half of 2021. In parallel, the Companies are scaling up manufacturing of the antigen and adjuvant respectively.

In addition to the recombinant protein-based vaccine in collaboration with GSK, Sanofi is developing a messenger RNA vaccine in partnership with Translate Bio. With several innovative vaccine platforms currently being investigated across the industry, mRNA is considered among the most promising.

Preclinical data showed that two immunizations of the mRNA vaccine induced high neutralizing antibody levels that are comparable to the upper range of those observed in infected humans. Sanofi expects the Phase 1/2 study to start in the fourth quarter of 2020, with earliest potential approval in the second half of 2021. Translate Bio has established mRNA manufacturing capacity and Sanofi expects to be able to supply annual capacity of 90 to 360 million doses.

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Covid Vaccine: Infections reported among Sputnik V trial volunteers

On August 11, Russia became the first country in the world to register the vaccine against coronavirus which was named Sputnik V.

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Moscow: There have been instances of infection among volunteers of Sputnik V trials, the world’s first registered vaccine against Covid-19 virus, according to a top official of the developer of the Russian vaccine, said a media report.

This is the reason why the developer of the vaccine, the Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Healthcare Ministry, is considering the possibility of disclosing the data on who among the volunteers were administered the vaccine, before summing up the results of the study, Russian news agency TASS reported on Wednesday.

Earlier, Deputy Research Director of the Gamaleya National Research Center, and Associate Member of the Russian Academy of Sciences, Denis Logunov, reported that trial participants will find out whether they received the vaccine or the placebo only after the end of tests.

The center’s director Alexander Gintsburg reported that the last group of volunteers out of the total of 40,000 may be inoculated by the end of January 2021.

“…Apparently, there are (coronavirus) infections (among the post-registration trials participants). At some point in mid-November the provisional results will be summed up, then we will find out the difference between the placebo and the test samples,” Gintsburg was quoted as saying to TASS.

In response to a question on how the results can be obtained before the end of the study if the data can be disclosed only after its completion, the director said that currently the center is thinking of introducing relevant amendments to the legislation.

The center’s director also explained that coronavirus infections among the volunteers may be related to the fact that an individual wasn’t vaccinated, that is, received the placebo.

On August 11, Russia became the first country in the world to register the vaccine against coronavirus which was named Sputnik V.

Russia faced criticism for approving a vaccine before conducting crucial phase-3 trials.

Post-registration trials of the preparation started in Moscow on September 7, with the first volunteers receiving the vaccine on September 9.

In all, 40,000 people participate in the program, 10,000 of whom will receive a placebo instead of the vaccine, TASS reported.

Earlier, the Janssen-Cilag company, the pharmaceutical division of US multinational Johnson & Johnson, temporarily suspended clinical trials in Brazil of a vaccine against Covid-19.

Before that, the Oxford Covid-19 vaccine trial was temporarily paused as one of the participants reported a suspected severe adverse reaction. The trial resumed after a safety review.

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Long-Term Exposure To Air Pollution Can Contribute To Mortality In Covid Cases: Top Medical Body ICMR

Every winter, the air quality in north India, including in Delhi, dips to a dangerous low. Experts have warned that high levels of air pollution can aggravate the COVID-19 pandemic.

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New Delhi: Studies in Europe and the US have established that long-term exposure to air pollution can contribute to mortality in COVID-19 cases, ICMR Director General Balram Bhargava said on Tuesday.

He stressed that studies have found “virus particles remain suspended with PM 2.5 particulate matter, but they are not active viruses”.

“There have been studies in Europe and the US, where they have looked at polluted areas and compared mortality during lockdown and correlation with pollution… they found that pollution is clearly contributing to mortality in COVID-19 and that’s well established by these studies,” Mr Bhargava said at a press conference.

Every winter, the air quality in north India, including in Delhi, dips to a dangerous low. Experts have warned that high levels of air pollution can aggravate the COVID-19 pandemic.

It is well-proven that pollution is related to mortality, Mr Bhargava said and asserted that the most inexpensive prevention for COVID-19 and pollution is rapid and widespread adoption of wearing masks.

He said in some cities with high pollution levels, people wear masks even when there is no pandemic.

“Following COVID-appropriate behaviour, be it wearing masks, maintaining social distancing, respiratory etiquette and hand hygiene, do not cost us anything. Wearing a mask has a double advantage as it can protect one from COVID-19 as well as from pollution,” the ICMR chief said.

About the spread of coronavirus infection among children in India, he said the country’s overall figure show that of the total COVID-19 positive cases, only eight per cent are below the age of 17.

“For those below five years, the figure would be probably less than one per cent,” Mr Bhargava said, adding there is some evidence that children “can be spreaders, rather super-spreaders”.

Long-Term Exposure To Air Pollution Can Contribute To Mortality In Covid Cases: Top Medical Body ICMR
Every winter, the air quality in north India, including in Delhi, dips to a dangerous low. (File)

New Delhi: Studies in Europe and the US have established that long-term exposure to air pollution can contribute to mortality in COVID-19 cases, ICMR Director General Balram Bhargava said on Tuesday.
He stressed that studies have found “virus particles remain suspended with PM 2.5 particulate matter, but they are not active viruses”.

“There have been studies in Europe and the US, where they have looked at polluted areas and compared mortality during lockdown and correlation with pollution… they found that pollution is clearly contributing to mortality in COVID-19 and that’s well established by these studies,” Mr Bhargava said at a press conference.

Every winter, the air quality in north India, including in Delhi, dips to a dangerous low. Experts have warned that high levels of air pollution can aggravate the COVID-19 pandemic.

It is well-proven that pollution is related to mortality, Mr Bhargava said and asserted that the most inexpensive prevention for COVID-19 and pollution is rapid and widespread adoption of wearing masks.

He said in some cities with high pollution levels, people wear masks even when there is no pandemic.

“Following COVID-appropriate behaviour, be it wearing masks, maintaining social distancing, respiratory etiquette and hand hygiene, do not cost us anything. Wearing a mask has a double advantage as it can protect one from COVID-19 as well as from pollution,” the ICMR chief said.

About the spread of coronavirus infection among children in India, he said the country’s overall figure show that of the total COVID-19 positive cases, only eight per cent are below the age of 17.

“For those below five years, the figure would be probably less than one per cent,” Mr Bhargava said, adding there is some evidence that children “can be spreaders, rather super-spreaders”.

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In response to a question, Mr Bhargava said that India, so far, has not reported any cases of Kawasaki disease among COVID-19 patients.
Kawasaki is an auto-immune disease that affects children who are less than five years and presents with fever, thrombocytosis and a condition in which the arteries of the heart become dilated.

“It is less common in India. This has been described with COVID-19 in different parts of the world. I don’t think we have had any experience of Kawasaki with COVID-19 in India so far. It is a very rare condition,” Mr Bhargava said.

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