Connect with us

Health

New method to make lung cancer drug trials more successful

Published

on

lung cancer

Melbourne, June 14:  Australian researchers have developed a new method for finding participants in clinical trials of lung cancer drugs, it was announced on Wednesday.

Researchers from Melbourne’s Walter and Eliza Hall Institute (WEHI) were optimistic that the new recruitment process will boost the success rate of drugs being trialled as treatments for lung squamous cell carcinoma, the second most common type of lung cancer.

By mimicking the complexity of human tumours with a research tool, the scientists were able to identify a “biomarker” which could serve as an indication as to which patients would better respond to certain drugs, Xinhua news agency reported.

Marie-Liesse Asselin-Labat, the lead author of the study, said patients with the biomarker were more likely to respond positively to fibroglast growth factor receptor (FGFR) drugs.

“We found that high levels of the anti-cancer drug’s target, FGFR1, in a patient’s tumour ribonucleic acid (RNA) were a better predictor of their potential response to the drug than the current tests that are used,” Asselin-Labat said on Wednesday.

Ben Solomon, a medical oncologist from the Peter MacCallum Cancer Centre, said the finding meant future clinical trials could be designed to succeed.

“Fewer than 10 per cent of new cancer drugs make it past phase 1 clinical trials. In many cases this isn’t because of the drug itself, but because of a limitation in clinical trial design,” Solomon said.

“Understanding which patients are most likely to respond to certain drugs in clinical trials is crucial both for patients to receive the best treatment, and for new drugs to make it to the clinic.”

“Hopefully these data will help to improve trial outcomes by recruiting patients who otherwise might not have been matched to the right trial for them,” Solomon said.

IANS

Health

Delhi govt planning free dialysis at pvt hospitals: Jain

Published

on

Dialysis

New Delhi, May 21 : The Delhi government is planning to make the dialysis procedure free at private hospitals and dialysis centres on a public-private-partnership basis, subject to conditions, Health Minister Satyendar Jain said today.

Jain said only those private hospitals and standalone centres which have more than 10 dialysis machines and are empanelled under the Delhi Government Employees Health Scheme or the Central Government Health Scheme would be eligible to become a partner in the project.

Delhi government through the Delhi Arogya Kosh will pay them Rs 1,274 per dialysis.

Delhi residents who have been living in the city for the past three years and having an annual income of less than Rs 3 lakh shall be eligible to avail the facility, Jain said.

The government is also installing dialysis machines at its own hospitals.

“We have installed 15 machines out of the 75 machines that we intend to install at various hospitals,” he said.

Jain said the idea behind providing the facility at private hospitals or dialysis centres is to cut the travel time for patients, who otherwise may have to go long distance to avail that facility at a government hospital.

“This would be like a reverse referral facility where patients would be referred to an empanelled hospital or centre nearby their home,” he said.

Jain said the government was in an “expansion mode” as far as health services were concerned.

“Five of our hospitals have already earned NABH entry-level accreditation – Pt Madan Mohan Malviya Hospital, Shri Dada Dev Matri Avum Shishu Chikitsalaya, Acharya Shree Bhikshu Hospital, Guru Gobind Singh Hospital and Dr Baba Saheb Ambedkar Hospital,” he said.

Continue Reading

Health

All you need to know about Nipah Virus

Published

on

Nipah Virus

New Delhi, May 21: Nipah Virus is an emerging infectious zoonosis that causes severe disease in both animals and humans. It was first reported in Malaysia in 1998.

It is spread by fruit bats and can be transferred from a human through close contact, body fluids, saliva and cough.

Nipah Virus first appeared in domestic pigs and has been found among several species of domestic animals including dogs, cats, goats, horses and sheep.

According to World Health Organisation (WHO), Nipah virus (NiV) infection is a newly emerging zoonosis that causes severe disease in both animals and humans. The natural host of the virus are fruit bats of the Pteropodidae Family, Pteropus genus.

At present, there is no vaccine for either humans or animals. The primary treatment for human cases is intensive supportive care.

NiV infection in humans has a wide range of clinical presentations, from asymptomatic infection to acute respiratory syndrome and fatal encephalitis.

Generally, the human infection presents as an encephalitic syndrome marked by fever, headache, drowsiness, disorientation, mental confusion, coma, and potentially death.

WeForNews 

Continue Reading

Health

Exercise 4-5 times daily to delay ageing

Published

on

exercise-workout-gym-yoga

New York, May 21: Want to stay young for long? If so, start exercising four to five times a day as it may help keep your heart stay healthy and slow down ageing, according to researchers.

Research showed that different sizes of arteries are affected differently by varying amounts of exercise.

While exercising for about two to three days a week for about 30 minutes may be sufficient to minimise stiffening of middle-sized arteries, exercising for about four to five days a week is required to keep the larger central arteries youthful.

The study would help “develop exercise programmes to keep the heart youthful and even turn back time on older hearts and blood vessels”, said one of the study authors, Benjamin Levine from the University of Texas.

With age, arteries — which transport blood in and out of the heart — become prone to stiffening, increasing the risk of heart diseases.

For the study, published in The Journal of Physiology, the team examined 102 people over 60 years old, with a consistent lifelong exercise history.

The participants were divided into four groups depending on their exercise history — Sedentary: less than 2 exercise sessions per week; Casual Exercisers: 2-3 exercise sessions per week; Committed Exercisers: 4-5 exercise sessions per week and Masters Athletes: 6-7 exercise sessions per week.

A lifelong history of casual exercise (two-three times a week) resulted in more youthful middle-sized arteries, which supply oxygenated blood to the head and neck.

However, committed exercisers (4-5 times per week) also had more youthful large central arteries, which provide blood to the chest and abdomen, in addition to healthier middle-sized ones.

Larger arteries need more frequent exercise to slow down ageing, the researchers said.

The findings will help see “if we can reverse the ageing of a heart and blood vessels by using the right amount of exercise at the right time”, Levine explained.

IANS

Continue Reading
Advertisement

Most Popular