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Indian-origin man in FBI ’10 Most Wanted’ list carries $100k reward

The FBI’s notice says that the accused “should be considered armed and extremely dangerous”.

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Bhadreshkumar Chetanbhai Patel,

New York, Nov 28 : The US’ Federal Bureau of Investigation (FBI) is reminding the public of a $100,000-reward offer for information leading to the capture of Indian-origin Bhadreshkumar Chetanbhai Patel, who has been listed by the agency as one of the “10 Most Wanted” since 2017.

Patel has been on the run since 2015 when he allegedly killed his wife, Palak, with a knife inside a Dunkin Donuts coffee shop in Hanover, Maryland state.

He has been charged with murder.

Although he was put on the list in 2017 with the $100,000 reward for information leading to his capture he has not been caught and on Friday the FBI tweeted information about him and the reward to draw attention to the case and the reward offer.

The FBI is asking anyone who knows where he is to contact the agency or the nearest US consulate or embassy.

Patel, who was 24 at that time, allegedly hit his 21-year-old wife in the face with a kitchen knife and stabbed her several times in the backroom of the shop where they both worked while customers were still there, according to officials quoted by WTOP radio.

He was last known to have taken a taxi from a hotel in New Jersey to a train station in Newark in the state.

Tim Altomare, who was the police chief of Anne Arundel County at that time, told the radio: “The violence in this case was stark. It was heart-wrenching and it was a shock to our collective conscience on the police department.”

WTOP reported that investigators think that Patel was still in the US in 2017 when he was put on the FBI list and according to Altomare investigators believe that someone was knowingly helping Patel or was interacting with him without knowing about his alleged crime.

The radio reported that according to Gordon Johnson, who was the special agent in charge of the FBI’s Baltimore field office in 2017, Patel was put on the list because of the brutality of the crime and the likelihood that someone outside the US knows where he was.

The couple’s visas expired about a month before the killing and investigators believe that Palak Patel wanted to return to India, but her husband opposed it, WTOP reported.

The FBI’s notice says that the accused “should be considered armed and extremely dangerous”.

According to the FBI he was born in Kantrodi Ta Viramgam in Gujarat.

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Male sex hormones may help treat breast cancer: Study

While endocrine therapy is standard-of-care for estrogen receptor positive breast cancer, resistance to these drugs is the major cause of breast cancer mortality.

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Sydney : Researchers have found new evidence about the positive role of androgens, commonly thought of as male sex hormones but also found at lower levels in women, in breast cancer treatment.

In normal breast development, estrogen stimulates and androgen inhibits growth at puberty and throughout adult life.

Abnormal estrogen activity is responsible for the majority of breast cancers, but the role of androgen activity in this disease has been controversial.

The new research published in the journal Nature Medicine showed that androgens have potential for treatment of estrogen receptor positive breast cancer.

A cancer is called estrogen receptor positive if it has receptors for estrogen, according to Breastcancer.org.

Using cell-line and patient-derived models, the global team, including researchers at the University of Adelaide and the Garvan Institute of Medical Research in Australia, demonstrated that androgen receptor activation by natural androgen or a new androgenic drug had potent anti-tumour activity in all estrogen receptor positive breast cancers, even those resistant to current standard-of-care treatments.

In contrast, androgen receptor inhibitors had no effect.

“This work has immediate implications for women with metastatic estrogen receptor positive breast cancer, including those resistant to current forms of endocrine therapy,” said lead researcher Theresa Hickey, Associate Professor at the University of Adelaide.

“We provide compelling new experimental evidence that androgen receptor stimulating drugs can be more effective than existing (e.g. Tamoxifen) or new (e.g. Palbociclib) standard-of-care treatments and, in the case of the latter, can be combined to enhance growth inhibition,” said Wayne Tilley, Director of the Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide.

Androgens were historically used to treat breast cancer, but knowledge of hormone receptors in breast tissue was rudimentary at the time and the treatment’s efficacy misunderstood.

Androgen therapy was discontinued due to virilising side effects and the advent of anti-estrogenic endocrine therapies.

While endocrine therapy is standard-of-care for estrogen receptor positive breast cancer, resistance to these drugs is the major cause of breast cancer mortality.

“The new insights from this study should clarify the widespread confusion over the role of the androgen receptor in estrogen receptor driven breast cancer,” said Elgene Lim, a breast oncologist and Head of the Connie Johnson Breast Cancer Research Lab at the Garvan Institute.

“Given the efficacy of this treatment strategy at multiple stages of disease in our study, we hope to translate these findings into clinical trials as a new class of endocrine therapy for breast cancer.”

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Azim Premji and Dr Devi Shetty chosen for PCB awards

Besides them 25 senior journalists have been selected for the ‘Press Club Annual Awards’, a release said.

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Azim Premji Wipro

Bengaluru, Jan 19: The chairman of Wipro Limited Azim Premji and the founder chairman of Narayana Health Dr Devi Prasad Shetty are among those who have been selected for the annual awards given by the Press Club of Bangalore.

Premji has been chosen for ‘Press Club Person of the Year’, while Dr Shetty and actor-Director Sudeep Sanjeev have been selected for the ‘Press Club Special Award.’

Besides them 25 senior journalists have been selected for the ‘Press Club Annual Awards’, a release said.

Chief Minister B S Yediyurappa will facilitate the awardees at a function scheduled for the third week of February, it said.

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Elizabeth Olsen: Nepotism creates fear that you don’t deserve the work you get

The actress added that she “always had this need to prove myself to everyone around me that I work really hard”, adding: “I couldn’t walk in a room without everyone already having an opinion.”

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Elizabeth Olsen

Los Angeles, Jan 19 : Hollywood star Elizabeth Olsen says she once thought of changing her surname and distance herself from the success of her family because it was insanity growing up in the spotlight.

“It was insanity. There were times when my sisters would always be spotted and I would be in the car with them and it would really freak me out. It has helped me navigate how I want to approach my career,” said the actress, whose older sisters are Mary-Kate Olsen and Ashley Olsen.

The actress added that she “always had this need to prove myself to everyone around me that I work really hard”, adding: “I couldn’t walk in a room without everyone already having an opinion.”

Elizabeth opened up om the fears of nepotism.

“The thing about nepotism is the fear that you don’t earn or deserve the work. There was even a part of me when I was a little girl that thought if I’m gonna be an actress I’m going to go by Elizabeth Chase, which is my middle name. And then, once I started working, I was like, ‘I love my family, I like my name, I love my sisters. Why would I be so ashamed of that?’ It’s fine now,” she said.

The actress said fame has made her more of a homebody.

“Fame has also made me someone who is more of a homebody than maybe I would like to be but I know where not to go. If I could do whatever I wanted for the day, I’d start with the gym, then I’d go to the grocery store, because it’s my favourite thing,” Elizabeth told The Sun.

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