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How human body ages?

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Japanese researchers have discovered metabolites that are specifically related to aging and shed light on how the human body ages.

Metabolites, substances that are created during metabolism, can provide a wealth of information about an individual’s health, disease, diet, and life-style.

The results of the study identified some metabolites in the blood that increased or decreased in the older adults.

The researchers found 14 age-related metabolites. Half of these decreased in elderly people and the other half increased.

Antioxidants and metabolites related to muscle strength decreased in the elderly, whereas metabolites related to declining kidney and liver function increased.

“Of the 14 compounds, half of the them had decreased in elderly people. The decrease was found in antioxidants and in compounds related to muscle strength. Therefore, elderly people had less antioxidants and less muscle strength,” said lead researcher Yanagida, professor at Okinawa Institute of Science and Technology Graduate University (OIST) in Japan.

In addition, some of the age-related metabolites found on the same metabolic pathways have connected changes, which suggests that age affects them simultaneously.

“Functionally related compounds show the same tendencies to increase or decrease with age, or in other words, they show similar correlations,” Yanagida noted, in the study published in the journal PNAS.

The decline in antioxidants and muscle strength suggest that it is important for individuals to consume foods high in antioxidants and to continue exercising, especially after the age of 65.

This could help increase the levels of the related metabolites in the body and improve body conditions, the researchers stressed.

“Longevity is a great mystery for us…We want to find how elderly people can live a happy final stage of life. This is the way we can contribute to human health,” Yanagida maintained.

To find and analyse the metabolites, the team obtained blood samples, including red blood cells (RBCs), from 30 healthy individuals: 15 young adults and 15 older adults.

Then, they used Liquid Chromatography-Mass Spectrometry (LC-MS), a technique that separates liquids and detects substances, to identify the metabolites within the blood.

From there, they could calculate the coefficients of variation, or the standard deviation of metabolite abundance divided by the average, to identify which compounds had increased or decreased in the older adults.

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Lifestyle

A Taste of Countryside of Philadelphia’s Wine Trails

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The vibrant hue of bold red. The floral nose of a crisp white. The dedicated art of winemakers who pour their heart, soul and experience into every bottle.
When you go wine tasting it’s not about sipping and savouring…although it’s certainly an enjoyable part of the day. It’s about experiencing a year-long process fueled by passion and literally getting a taste of craftsmanship.

The gentle rolling hills, deep well-drained soils, and moderate climate combine to make the Countryside of Philadelphia one of the premier grape growing regions of the East Coast. Several vintners have joined together to establish three wine trails in Philadelphia’s Countryside: The Brandywine Valley Wine Trail (35 miles from Center City) bridges Chester County wineries. The Bucks County Wine Trail (35 miles from Center City) unites wineries just north of Philadelphia. And The Montgomery County Wine Trail (25 miles from Center City) runs northwest of the city.

Brandywine Valley Wine Trail

Beautiful estate vineyards in the rolling hills of Chester County, PA. Charming tasting rooms and barrel-aging cellars filled with premium wines that showcase the unique terroir of the region. Spanning scenic southeastern Pennsylvania between historic Philadelphia and the Amish countryside outside Lancaster, the six wineries of the Brandywine Valley Wine Trail are located within an easy drive of one another (within a 50 mile radius). Wine Trail wineries include Black Walnut Winery, Borderland Vineyard, Kreutz Creek Vineyards and Paradocx Vineyard.

All wineries are open year round for your enjoyment. So come visit the tasting rooms and learn more about the unique characteristics of Brandywine Valley Wine Country!

The Bucks County Wine Trail

The formation of a Bucks County Wine Trail was initially considered in 2003, with several Bucks County, Pennsylvania wineries pooling time, resources and ideas. They incorporated as a nonprofit organization in 2004. Additional wineries opened in the county or joined, and today they comprise seven wineries.
The Bucks County Wine Trail comprises seven local wineries: Bishop Estate Vineyard and Winery; Buckingham Valley Vineyards; Crossing Vineyards and Winery; Rose Bank Winery; Rushland Ridge Vineyards; Sand Castle Winery; and Wycombe Vineyards.
Every winery has its own operating hours, unique tasting experiences, applicable per person tasting fees and, in some cases, special events and on-site tours. There is not a trail-wide ticket available to tour all of the wineries. Instead, we invite guests to visit our wineries at their leisure. Many of the wineries can assist you in arranging a tour with a bus or travel company if you so desire.

See how wine is produced. Talk with the people who make it happen. Tour the cool wine cellars. Experience history in the making.

The Montgomery County Wine Trail

With only four wineries, the Montgomery County Wine Trail is Pennsylvania’s smallest wine trail and the region’s newest. Each of the four wineries coexist alongside old stone houses, 18th-century taverns and lush golf courses.
The trail features more than 30 varieties of wine, including Reserve Reds, French Hybrid Whites, 100% Fruit Wines (no added flavors), Meads (Honey Wines), ciders, dessert wines and also amazing Port wines.
The wine trail wineries are in farmers markets like Lansdale, Glenside and Ambler. At Cardinal Hollow Winery,you can learn about how grapes are grown, harvested, processed and handled on the way to becoming wine whereas at Stone & Key Cellars, you can enhance your appreciation for fine wine and winemaking tradition with hands-on experience at a modern winery.

No matter where you are in the countryside, you are not more than 45 minutes from a winery.

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Lifestyle

World Breastfeeding Week 2020: 10 essential nutrition tips for mothers

Calcium is vital for lactating mothers as they lose up to 15 percent of their own body calcium and about 3-5 percent of their bone mass while nursing their baby.

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Breastfeeding

New Delhi: For women who have recently become mothers, a healthy and nutritious diet is essential to boost lactation, just as much as its essential for a newborn to get its share of required nutrition. This makes it mandatory for the mother to consume food that will benefit her physical health and give her enough energy to combat post-pregnancy pressures, especially with the pandemic disrupting our daily lives.

This World Breastfeeding Week, Rohit Shelatkar, VP at Meyer Vitabiotics and Fitness and Nutrition Expert shares ten essential nutrients tips for new mothers :

Calcium: Babies need to develop their bone structure, and calcium is the best aid for that. It plays a crucial role in development of the new born baby’s teeth, and thus needs to be included in the diet for lactating mothers. Milk, cheese, yogurt, tofu and nuts are some of the foods that are rich in calcium and must be consumed. Calcium is vital for lactating mothers as they lose up to 15 percent of their own body calcium and about 3-5 percent of their bone mass while nursing their baby.

Protein: Inclusion of protein is crucial because it serves as the tissue’s building blocks and fosters growth. The new-born baby needs these nutrients and so the new mother must incorporate eggs, lean meat, fish, peanut butter and beans to her diet.

Omega 3: A crucial source of Docosahexaenoic Acid (DHA), Omega 3 fatty acids offer a host of benefits including aiding the development of the baby’s eyes and brain, reducing risk of chronic diseases, decreasing effects of ADHD, and more. The best source for Omega 3 fatty acids is fish like salmon and trout and alternatively, for vegetarian mothers, flaxseed, soy, walnuts and pumpkin seeds are good sources for Omega 3.

Probiotics: Probiotics are ‘good’ bacteria that helps fight ‘bad’ bacteria that cause infections. This is important for the new born, as during this time their immune system is still weak. Yogurt, paneer, green peas, kimchi, pickles, idli and buttermilk are excellent sources of probiotics that should be incorporated during meal time.

Iron: Iron aids in the development of the brain and blood cells for the baby and should be a part of the new mother’s diet. Lentils, beans, tofu, spinach and cashews are natural sources of iron and must be incorporated into their meal plan. Iron is also an essential nutrient for new mothers because there is loss of blood during the delivery, followed by tiredness and long nights with the infant and iron consumption helps cope with that.

Moderating caffeine intake: After nine months of avoiding caffeine, new mothers can finally enjoy a cup of coffee again, but in moderation, as excess intake of caffeine can leak into the mother’s breast milk and reach the baby’s system.

Consider Supplements: It is recommended to consume a daily vitamin B-12 supplement. Vitamin B-12 is found mostly in animal products, so it’s difficult to get enough in vegetarian diets. Additionally, Vitamin D supplements help absorb calcium and phosphorus. New mothers should consider adding these to their daily diet.

Be Moderately Active: It is perfectly fine to perform physical activity for new mothers while breastfeeding and that won’t affect the baby’s growth or milk supply. Moderate intensity activities like brisk walking or riding a bike on a level surface about three or four times a week can help reduce stress levels, improve energy levels and build bone strength.

Avoiding empty calories: The first few days after delivery are very hectic, and it is extremely tempting for the new mother to turn to comfort food or junk food. These types of food contain a number of empty calories that can affect insulin levels in the body which can lead to obesity.

Avoid Smoking or Drinking Alcohol: This is a big ‘no’ for breast-feeding mothers as the harmful toxins transfer to the baby via the milk. Additionally, it is important not to use any medication that is not approved by the doctor.

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India

Legacy of India’s unity is in its diversity, must be upheld: Mamata

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Mamata Banerjee

Kolkata, Aug 5 : On the day when the nation is celebrating the ‘bhumi pujan’ ceremony of the grand Ram Temple in Ayodhya, West Bengal Chief Minister Mamata Banerjee on Wednesday said that the nation has always upheld its legacy of unity in diversity.

“Hindu, Muslim, Sikh, Isaai, Aapas mein hain Bhai Bhai! Mera Bharat Mahaan, Mahaan Hamara Hindustan (Hindu, Muslim, Sikh and Isaai are our brothers. India is great. Hindustan is great),” Banerjee tweeted.

She also said that India has always upheld the age-old legacy of unity in diversity. “And we must preserve this to our last breath,” Banerjee added.

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