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How home environment can put kids at depression risk later

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New York, April 29 (IANS) Researchers have found that children’s rearing environment has a major impact on their risk for major depression later in life.

For the findings, published in the American Journal of Psychiatry, the research team analysed the health records of full and half-siblings with at least one biological parent with depression who were raised by either their biological parents or in carefully screened adoptive homes.

Generally, the children in adopted homes showed lower risk, but whatever the setting, episodes of major depression in the parents meant the children were more susceptible to depression themselves, the researchers from Virginia Commonwealth University (US) and Lund University (Sweden) said.

They identified 666 high-risk full sibling pairs and 2,596 high-risk pairs of half-siblings each with at least one child reared at home and one adopted. High risk was defined as having at least one biological parent with major depression.

In Sweden, the adoptive parents are carefully screened and undergo a rigorous selection process to ensure their ability to “provide a supportive and generally advantaged home for their adoptive child.”

In the full sibling group, the risk for major depression among adopted siblings was 23 per cent lower than the sibling raised in the home with their birth family.

In the group of half-siblings, the risk of depression was 19 per cent lower for the adopted siblings.

For both the full and half-sibling groups, the protective effect of adoption disappeared when an adoptive parent or step-sibling had major depression.

According to the study, results demonstrate the strong impact of the rearing environment on risk for major depression and support the importance of intervention efforts to improve the rearing environment in high-risk families.

The study authors concluded that their results “further strengthen the evidence that high-quality rearing environments can meaningfully reduce rates of major depression in individuals at high familial risk.”

Health

The goodness of Argan oil

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Argan oil has traditionally been used topically to improve the health of skin, hair, and nails. It contains a number of different beneficial properties and vitamins that form a powerful combination to boost skin health.

Dr Geeta Grewal – cosmetic surgeon, beauty and health wellness expert explains some prominent uses of the oil for health, skin and hair.

Night Moisturiser

Argan oil absorbs quickly and does not leave an oily residue. In the winter months you may need a second drop but remember to use sparingly. This oil is safe and gentle to use around your eyes. Vitamin A and Vitamin E present in the oil can help to reduce fine wrinkles and keep this delicate area moisturized.

Skin Toner

Toning is an important step in your skin care routine. For an all-over glow, add 3-4 drops of your favourite toner, make your own chemical-free, natural toner at home.

Exfoliant

To experience the argon oil benefits while exfoliating, pay special attention to acne-prone areas and areas that are dry.

Regular exfoliation helps to remove dead skin cells and reduce the appearance of fine lines and wrinkles, while giving you a younger, fresher complexion. With the aid of the brown sugar, argon oil’s nutrients are more readily absorbed into your skin. Use this exfoliator for more than just your face. If you have dry elbows or heels, mix up a bit more to massage the dry and dead skin away.

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Health

Natural antioxidants can keep heart, cancer diseases at bay

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If you want to keep your immune system strong for fighting cardiovascular diseases or cancer, start taking natural antioxidants as health experts on Sunday stressed that it helps in improving overall health by providing many other health benefits.

According to experts, antioxidants are substances that may protect your cells against free radicals, which play a role in heart disease, cancer and other diseases.

Free radicals are molecules produced when your body breaks down food or when you’re exposed to tobacco smoke or radiation.

The latest antioxidant which is produced for the first time in India is gamma oryzanol, which is very quickly gaining popularity as a super antioxidant.

It is a substance that is taken out of rice bran oil. It is also found in wheat bran and some fruits and vegetables.

The experts said that gamma oryzanol is used for high cholesterol, symptoms of menopause and many other conditions.

“Gamma oryzanol is useful for controlling elevated cholesterol and triglyceride levels, supporting cardiovascular health along with controlling menopausal symptoms. Gamma oryzanol helps lower cholesterol because it helps decrease cholesterol absorption and increase cholesterol elimination. Along with this, it is also known to boost metabolic rate and may help with weight loss,” Swapna Chaturvedi, senior dietician, Department of Dietetics, AIIMS told IANS.

As gamma oryzanol is found to be effective in controlling high cholesterol level in the body, it is registered in Japan and the US as a natural medicine to treat hyperlipidemia/dyslipidaemia (elevated cholesterol levels/unhealthy cholesterol levels.

Most research shows that taking natural antioxidants decreases total cholesterol, “bad” low-density lipoprotein (LDL) cholesterol, and blood fats called triglycerides in people with high cholesterol.

“It also helps in preventing heart attack by preventing platelet aggregation, a system where platelets blood gets stuck together and form clots that block arteries,” said Praveen Chandra, Head of Department, Interventional Cardiology, Medanta, The Medicity in Gurugram.

The experts mentioned that gamma oryzanol is also used for increasing testosterone and human growth hormone levels, as well as improving strength during resistance exercise training.

Gamma oryzanol also helps to inhibit different cancers in the body and builds immunity to fight cancer cells.

“Many of the antioxidants have proven beneficial in inhibiting the cancers at various stages. Gamma oryzanol has been found out to be effective antioxidant which comes from rice bran and helps in preventing cancer if taken for a long period,” said Rahul Bhargava, Director, Institute of Blood Disorder and BMT, Fortis Hospital, New Delhi.

Gamma oryzanol is basically activator of NK cells which gives the cancer cells a check.

It not only works through NK cells but also inhibits angiogenesis. It means it cuts the supply for the cancer cells to grow and increases your body’s own immunity to gather the strength to kill cancers.

“Gamma oryzanol also prevents cancers and studies show it helps in regressing the prostate cancer cells,” Bhargava noted.

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Male sex hormones may help treat breast cancer: Study

While endocrine therapy is standard-of-care for estrogen receptor positive breast cancer, resistance to these drugs is the major cause of breast cancer mortality.

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Sydney : Researchers have found new evidence about the positive role of androgens, commonly thought of as male sex hormones but also found at lower levels in women, in breast cancer treatment.

In normal breast development, estrogen stimulates and androgen inhibits growth at puberty and throughout adult life.

Abnormal estrogen activity is responsible for the majority of breast cancers, but the role of androgen activity in this disease has been controversial.

The new research published in the journal Nature Medicine showed that androgens have potential for treatment of estrogen receptor positive breast cancer.

A cancer is called estrogen receptor positive if it has receptors for estrogen, according to Breastcancer.org.

Using cell-line and patient-derived models, the global team, including researchers at the University of Adelaide and the Garvan Institute of Medical Research in Australia, demonstrated that androgen receptor activation by natural androgen or a new androgenic drug had potent anti-tumour activity in all estrogen receptor positive breast cancers, even those resistant to current standard-of-care treatments.

In contrast, androgen receptor inhibitors had no effect.

“This work has immediate implications for women with metastatic estrogen receptor positive breast cancer, including those resistant to current forms of endocrine therapy,” said lead researcher Theresa Hickey, Associate Professor at the University of Adelaide.

“We provide compelling new experimental evidence that androgen receptor stimulating drugs can be more effective than existing (e.g. Tamoxifen) or new (e.g. Palbociclib) standard-of-care treatments and, in the case of the latter, can be combined to enhance growth inhibition,” said Wayne Tilley, Director of the Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide.

Androgens were historically used to treat breast cancer, but knowledge of hormone receptors in breast tissue was rudimentary at the time and the treatment’s efficacy misunderstood.

Androgen therapy was discontinued due to virilising side effects and the advent of anti-estrogenic endocrine therapies.

While endocrine therapy is standard-of-care for estrogen receptor positive breast cancer, resistance to these drugs is the major cause of breast cancer mortality.

“The new insights from this study should clarify the widespread confusion over the role of the androgen receptor in estrogen receptor driven breast cancer,” said Elgene Lim, a breast oncologist and Head of the Connie Johnson Breast Cancer Research Lab at the Garvan Institute.

“Given the efficacy of this treatment strategy at multiple stages of disease in our study, we hope to translate these findings into clinical trials as a new class of endocrine therapy for breast cancer.”

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