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Here’s how belly fat could raise your cancer risk

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New York, Aug 25: Belly fat may release more of a protein that can cause a non-cancerous cell to turn into a cancerous one, new research has found.

Obesity has been linked to several types of cancers including that of the breast, colon, prostate, uterus or kidney, but the new study, published in the journal Oncogene, indicated that just being overweight is not necessarily the best way to determine risk.

“Our study suggests that body mass index, or BMI, may not be the best indicator,” said lead author Jamie Bernard, Assistant Professor at Michigan State University in the US.

“It’s abdominal obesity and, even more specifically, levels of a protein called fibroblast growth factor-2 that may be a better indicator of the risk of cells becoming cancerous,” Bernard added.

There are two layers of belly fat. The top layer, known as subcutaneous fat, lies right under the skin. The layer under that, called visceral fat, is the one she found to be more harmful.

Bernard and her co-author Debrup Chakraborty, a postdoctoral student in her lab, studied mice that were fed a high-fat diet and discovered that this higher-risk layer of fat produced larger amounts of the fibroblast growth factor-2, or FGF2, protein when compared to the subcutaneous fat.

They found that FGF2 stimulated certain cells that were already vulnerable to the protein and caused them to grow into tumours.

Bernard also collected visceral fat tissue from women undergoing hysterectomies and found that when the fat secretions had more of the FGF2 protein, more of the cells formed cancerous tumours when transferred into mice.

“This would indicate that fat from both mice and humans can make a non-tumorigenic cell malignantly transform into a tumorigenic cell,” Bernard said.

There are several other factors released from fat, including the hormone estrogen, that could influence cancer risk, but many of those studies have only been able to show an association and not a direct cause of cancer, Bernard said.

Genetics too play a role, she added.

IANS

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Over 60K sign up for Russian Covid vax, 700 injected

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More than 60,000 people have applied to volunteer for the coronavirus vaccine trials in Moscow and over 700 people have been injected with the coronavirus vaccine, the media reported

Sputnik V, an adenovirus vector-based vaccine, was developed by the Gamaleya Scientific Research Institute of Epidemiology and Microbiology, along with the Russian Direct Investment Fund and registered on August 11.

Over 60,000 people have signed up as volunteers, several thousand people have passed the required medical tests to be registered as potential candidates for carrying out the tests,” Mayor Sergei Sobyanin was quoted as saying in reports on Sunday.

According to Russian Tass news agency, more than 700 people have been injected with the coronavirus vaccine.

“All of them are feeling good,” Sobyanin said.

The vaccine was developed on a platform that had been used for a number of other vaccines.

On August 15, the Russian Health Ministry announced the launch of the vaccine production.

The Russian Direct Investment Fund (RDIF) and Dr Reddy’s Laboratories Limited, a global pharmaceutical company headquartered in India, have also agreed to cooperate on clinical trials and distribution of Sputnik V Covid-19 vaccine in India.

“On regulatory approval in India, RDIF shall supply to Dr Reddy’s 100 million doses of the vaccine. The Sputnik V vaccine, which is based on well-studied human adenoviral vector platform with proven safety, is undergoing clinical trials for the coronavirus pandemic,” said a statement from the fund.

The Russian Direct Investment Fund said that the deliveries could potentially begin in late 2020 subject to completion of successful trials and registration of the vaccine by regulatory authorities in India.

Earlier this month, a study published in the peer-reviewed journal The Lancet said a Russian Covid-19 vaccine has shown no serious side effects and elicited an immune response in early human trials.

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11-kg tumour extracted from Mumbai woman’s abdomen

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Mumbai, Sep 20 : Doctors in Mumbai have extracted a gigantic 11-kg tumour from the abdomen of a 55-year-old woman after a marathon nine-hour surgery.

A team of medicos headed by oncologist Dr Tanveer A. Majeed, urologist Dr Santosh Palkar and Dr Shilpa Deshmukh performed the complicated surgery at the Zen Multispeciality Hospital in Chembur.

The patient Sujata Sinha (name changed) is a housewife who noticed her abdomen growing daily accompanied by breathing difficulties.

At the height of lockdown in June, she consulted a local doctor who confirmed the presence of a tumour with ultrasound and CT scan.

However, owing to the lockdown she did not take any further steps or medicines, even as the tumour continued to grow rapidly, making her look obese.

Finally, she was referred to the ZMH and Dr Majeed checked her condition on September 8 to find she was weighing around 80 kgs, and suffered from diabetes and hypertension.

Further tests revealed the huge abdominal tumour encroaching the right half of the abdomen, pushing the right kidney to the left side, duodenum, liver, small intestine and colon to the left side, besides her major blood vessels supplying to the heart.

After further clinical diagnosis, the patient was advised surgery by Dr Majeed as it indicated a rare cancer of connective tissues that resemble fat cells under a microscope.

“After opening the abdomen, we found a huge tumour which had displaced all the other body organs to the left side. It weighed 11 kgs and had dimensions of 55 cm x 40 cm x 35 cm, and the patient lost around one litre of blood during the nine-hour operation,” said Dr Majeed.

The patient is recuperating well at the hospital now, has started an oral liquid diet, can breathe normally, and will be required for a follow-up after three months.

“We delayed treatment due to the pandemic lockdown. But I am fortunate to be operated at ZMH where the doctors saved my life. I feel much lighter now, can eat and breathe properly and resume normal life,” said the patient gratefully.

Prior to this, a team of doctors at the Global Hospital, Parel, had extracted a massive 12-kg tumour from a woman’s abdomen in December 2014.

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Uttar Pradesh man nabbed for importing drugs from United States

He used to order the drugs from the US through Instagram or Wickr and the payments were made through bitcoins.

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Lucknow, Sep 20: The Narcotics Control Bureau (NCB) has arrested a person from here and seized 2.7 kg of bud (curated marijuana) concealed in an air compressor machine at Delhi.

The consignor is based in the US and a few earlier seizures made by NCB had the same origin which alerted the NCB team.

The payment for the consignment was made through bitcoins and came into contact through Instagram ID of the consignor.

According to the NCB press statement, the parcel was sent to India from the US on August 31.

A detailed investigation into the case with the help of digital analysis led NCB team to the consignee C. Gidwani, a Lucknow resident, who accepted his involvement in the case on September 18.

The necessary digital evidence was also seized. He admitted that he used to import such parcels on a regular basis for last one and a half years for himself and further distribution to his friends.

He used to order the drugs from the US through Instagram or Wickr and the payments were made through bitcoins.

The accused also revealed that he used to get ‘charas’ and ‘marijuana’ from Delhi and Bangalore-based suppliers. Further investigations into the backward and forward linkages were underway.

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