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Heavy, tall kids at higher risk of kidney cancer

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Kidney Cancer
Heavier and taller children are at higher risk of kidney cancer (Representative Image)
London, April 30: Heavier and taller children are more likely to develop kidney cancer as adults than their average-sized peers, warn researchers.

“We know that overweight in adulthood is associated with an increased risk of renal cell carcinoma (RCC). We also know that cancers take many years to develop. We, therefore, had a theory that already being overweight in childhood would increase the risk of RCC later in life,” said lead author Britt Wang Jensen from Bispebjerg and Frederiksberg Hospital in Denmark.

RCC is the most common form of kidney cancer found in adults.

For the study, the researchers included 301,422 individuals from the Copenhagen School Health Records Register born from 1930 to1985.

The weights and heights were measured at the ages seven to 13 years, and body mass index (BMI) was used to categorise the children as normal-weight or overweight, suggested by the International Obesity Task Force.

During a median of 32 years of observation, 1,010 individuals (680 men) were diagnosed with RCC.

Among men and women, significant and positive associations were observed between childhood BMI and height, respectively, and RCC risk.

Children who grew from average to above average height had an eight per cent increased risk of RCC, the study said.

“Our findings that heavier and taller children have increased risks of RCC open the door to new ways to explore the causes of kidney cancer,” Jensen said.

The study was presented at the European Congress on Obesity being held in Glasgow, Scotland from April 28 to May 1.

IANS

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New drug to protect against Alzheimer: Study

“Such observations imply that Alzheimer’s pathology can be tolerated by the brain to some extent due to compensatory mechanisms operating at the cellular and synaptic levels,”

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New York, Sep 10 : Researchers have discovered a new drug which may protect against memory loss, nerve damage and other symptoms of Alzheimer’s disease.

Preclinical research published in the Journal of Pharmacology and Experimental Therapeutics found that the drug — called BPN14770 — deters the effects of amyloid beta, a hallmark protein of Alzheimer’s that is toxic to nerve cells.

BPN14770, under development by Tetra Therapeutics, could help activate these mechanisms that support nerve health and prevent dementia, even with the progression of Alzheimer’s.

“Such observations imply that Alzheimer’s pathology can be tolerated by the brain to some extent due to compensatory mechanisms operating at the cellular and synaptic levels,” said study researcher Ying Xu, Associate Professor at University at Buffalo.

“Our new research suggests that BPN14770 may be capable of activating multiple biological mechanisms that protect the brain from memory deficits, neuronal damage and biochemical impairments,” Xu added.

The research conducted in mice, discovered that BPN14770 inhibits the activity of phosphodiesterase?4D (PDE4D), an enzyme that plays a key role in memory formation, learning, neuroinflammation and traumatic brain injury.

PDE4D lowers cyclic adenosine monophosphate (cAMP) — a messenger molecule that signals physiological changes such as cell division, change, migration and death — in the body, leading to physical alterations in the brain.

cAMP has numerous beneficial functions, including improved memory. By inhibiting PDE4D, BPN14770 increases cAMP signalling in the brain, which ultimately protects against the toxic effects of amyloid beta.

“The role of PDE4D in modulating brain pathways involved in memory formation and cognition, and the ability of our PDE4D inhibitor to selectively enhance this process, has been well studied,” said Mark E. Gurney from Tetra Therapeutics.

“We are very excited by our colleagues’ findings, which now suggest a second protective mechanism of action for BPN14770 against the progressive neurological damage associated with Alzheimer’s disease,” Gurney said.

“Developing effective drugs for memory deficits associated with Alzheimer’s disease has been challenging,” said M. O’Donnell, Professor at University at Buffalo.

“BPN14770 works by a novel mechanism to increase cyclic AMP signalling in the brain, which has been shown to improve memory. The collaborative project has led to clinical trials that will begin to test its effectiveness,” O’Donnell said.

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First swine flu case confirmed in Philippines

In Vietnam, more than 2.6 million pigs have been culled in an attempt to control the spread of the disease.

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Swine flu fever

Manila, Sep 9 (IANS) The Philippines government on Monday confirmed the first case of swine flu recorded in the country, the latest to be affected by a virus that poses a grave threat to the Southeast Asian region’s food security.

Hundreds of pigs from various backyard farms died in at least two provinces due to the disease, which does not affect humans but will, according to the UN Food and Agriculture Organization (FAO), potentially endanger the livelihoods of millions of people.

Agriculture Minister William Dar told the media on Monday that 14 of the 20 blood samples from the provinces of Rizal and Bulacan, located near the capital, Manila, had tested positive, Efe news reported.

Dar said that President Rodrigo Duterte has approved the creation of a special team to fight the potential outbreak of the virus, which has until now affected some 7,400 pigs.

Since the detection of one of the first cases in August 2018 in China, the epidemic has spread across the Asian giant and has also affected Mongolia, Cambodia and Laos.

In Vietnam, more than 2.6 million pigs have been culled in an attempt to control the spread of the disease.

The virus causes a highly contagious disease that affects pigs living in farms and no vaccine exists to counter it, which is why mass slaughter remains the only option to contain its spread.

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Watch: Union Minister Ashwini Choubey Sees Cure For Cancer In Cow Urine

Over the years, several leaders of the ruling BJP have advocated the use of cow dung and urine in daily life on account of its purported curative qualities.

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ashwini choubey

Union Minister Ashwini Choubey on Saturday attested to the significance of cow urine in the health sciences, saying that it can be used to treat serious ailments that have long baffled medical practitioners.

“Several medicines, including those used to treat cancer, are prepared using cow urine. The centre is also working on this under the Ayushman Bharat Yojana,” he was heard telling reporters at Coimbatore, Tamil Nadu, in a video released by news agency ANI. Mr Choubey, who is the Minister of State for Health, also said that every effort was being made to protect cattle through proper implementation of government schemes.

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