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Facts to consider for cancer patients amid ongoing coronavirus pandemic

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Coronavirus

The world has been rattled by the ongoing coronavirus infection (COVID19) which started from the city of Wuhan, China somewhere in late 2019. So far, more than a million people have been infected worldwide — there have been over 50,000 deaths involving more than two hundred countries.

In 2018, WHO estimated almost 9.6 million deaths worldwide due to cancer (almost 1 in every 6 deaths). Many of these cancers require immediate attention and treatment. Delay in treatment is known to jeopardize treatment outcomes in most situations.

When the entire world is busy fighting the highly contagious virus , cancer patients are finding it difficult to understand and respond to this situation adequately. Even oncologists across the globe are in a fix due to lack of data of coronavirus infection and its implication on cancer patients.

Let us have a look at the common concerns at this moment and suggest some practical solutions with examples of some common cancers.

Q: What is the data specific to coronavirus infection in cancer patients?

A: Very less. Only one Chinese data with roughly 2,000 patients from 575 hospitals across 31 provinces is available at present. They identified 18 patients with a history of cancer. This rate is higher than their usual national cancer occurrence pattern suggesting slightly higher risk of cancer in patients being affected with coronavirus infection. Also, patients with cancer had more severe events. It is important to understand that no concrete conclusion can be drawn from only 18 patients’ data

Q: Are the symptoms of coronavirus infection same as in other patients?

A: As of now there is nothing to suggest that they are different. The common symptoms are fever, dry cough, sore throat, fatigue, breathing difficulty, diarrhoea etc. Severe infection can give rise to severe pneumonia like features.

Q: Which conditions make corona infection worse?

A: Few conditions make the situation worse. These include but are not limited to diabetes, heart disease, high blood pressure, immunosuppressed states (including cancer) etc.

Q: Can corona infection risk be more in cancer patients?

A: Scientists are learning new things about coronavirus infection. The only Chinese data suggests some increased risk but that is yet to be confirmed in larger population data.

Q: Why are cancer patients more at risk?

A: Few cancers and their spread to other organs reduce the body’s immunity. Different anticancer treatments like radiation, chemotherapy or immunotherapy can lead to immunosuppression. Few cancers require bone marrow transplant and they are at increased risk due to immunosuppressed state. Cancer can also be associated with anorexia, poor nutrition, cachexia which can reduce immunity further.

Q: Which cancers are at more risk?

A: There is no single answer to this question. However, few cancers like blood cancers (acute leukemia, chronic leukemia, lymphoma), cancers requiring bone marrow transplant; cancers requiring immunosuppressive chemotherapies, cancers requiring radiation to an area of the body involved in production of blood etc. are at more risk of severe complications from coronavirus infection. It is always important at this moment to ask your treating team of doctors about the risk of immunosuppression.

Q: Do all cancers require immunosuppressive therapies?

A: Perhaps no. However, it is impossible to answer in one single word or sentence. There might be some cancer and treatment which does not cause significant immunosuppression. Ask your physician to know if your cancer falls in that category or not.

Q: When will my immunity become normal once again?

A: Again, it is difficult to answer. Usually chemotherapies are given in a cyclical repetitive manner. During this time, immunity level also varies. Depending on the type and nature of this chemotherapy cycle, lowest immunity time also varies. Some treatments can cause prolonged immunosuppression. Please inquire with your caregiver regarding this and take necessary precautions.

Q: Should I start my treatment right now?

A: Starting and completing cancer treatment in a timely manner is important to maximize the benefits. Some cancers are less aggressive whereas others are more aggressive. For example, some prostate cancers are slowly growing and perhaps may not require immediate treatment. On the other hand, a breast cancer in a young woman or a lung cancer with aggressive nature or advanced stage may need immediate attention. Sometimes alternative treatment regime and schedule can reduce the frequency and number of hospital visits. This is applicable to both chemotherapy and radiation. Please discuss with your doctor regarding these alternative treatment approaches.

Q: I have almost completed my treatment. Is it safe to discontinue treatment in between?

A: It is not wise to stop treatment in between without discussing with your doctor.

Q: How can I increase my immunity?

A: There is no proven evidence that your immunity against coronavirus infection can be boosted by drugs or other things. Scientists are working on that. You can continue taking a healthy diet, continue your regular physical activities to keep yourself healthy and fit. Vitamin C, lemon, Ginger, Turmeric, Garlic etc. are as such good for health. However, it is important to understand that none of the above food or spices or herbs are effective in preventing or treating coronavirus infection. During treatment, you may be given colony stimulating factors to increase your blood cell counts. However, it is not proven if that gives protection against the corona virus or not.

Q: Is it safe to use public transport?

A: At this moment it is better to avoid all public transports. Use your personal transport if possible. However, if you at all need to use public transport, try to maintain physical distancing as much as possible. Use basic self-protection (like wearing a mask, avoiding people with symptoms of cold or cough or sick people etc.), carry your personal hand sanitizer and apply liberally when you touch any object or surface of the transport etc. Carry as minimum objects as possible.

Q: What precautions should I take?

A: Some basic precautions which are applicable to all, like:

  • Wash your hands properly with soap water for 20-30 seconds. Do this as many times as possible, after every coughing or sneezing before touching anything else. If you cannot wash hands, you can also use alcohol-based hand rub (at least 60-70 per cent alcohol concentration
  • Physical distancing of at least 1-2 meters
  • Protect your face by covering with mask
  • Do not touch your mouth, nose, eyes unnecessarily. If required, sanitize your hands before and after touching the surface. You can use a goggle to protect your eyes
  • Sanitize your car steering or places where you touch with your hands
  • Change your dress immediately after reaching home. Keep them in a safe place not to be touched by others for five or six hours before washing with soap or detergent. It is better not to shake the cloth as that may dislodge any droplets or virus in it. If possible, use one set of cloth for one day.
  • Do not touch hospital surfaces unnecessarily like walls, side rails of staircase etc.
  • Maintain shoe hygiene. Droplets can reach home by contaminated shoe as well. Keep outdoor shoes away and use a separate pair for home.
  • Sanitize the places at home where people touch very commonly like calling bell, doorknob etc.
  • If you are an in-patient, ask your health care provider to follow hand hygiene and other protective steps properly.

Q: Any special precautions if I am undergoing radiation?

A: Yes. Follow all the basic steps as outlined above. Additionally:

  • Inside the radiation area you may need to change your dress. Be careful inside change room and avoid any source of infection
  • Be careful when you are lying down on a simulation table or radiation treatment table. Ensure that proper sanitization was done before you entered the room.
  • Ensure that staff delivering the treatment are following hand hygiene protocols.
  • Ensure that the thermoplastic mask you are putting on is not contaminated by other’s mask.
  • Sanitize your hands after your simulation or radiation delivery is over
  • In any doubt, inquire with your radiation oncologist for the same.
  • Discuss if a shorter course of treatment is useful without compromising the outcome for you.

Q: I am due for my routine follow up. Should I visit the hospital right now?

A: If you are not in an emergency situation and if it is a routine follow-up, you can discuss with your oncologist if an electronic discussion can be useful or not. You can talk over the phone or email your symptoms if any for understanding your need. It is better to avoid routine hospital visit at present.

Even after saying all these, please understand that this virus is very much new to the scientific community and facts related to cancer patients are very rare at present. All cancers are different, every patient is different from the other one, treatments are customized, and one size does not fit all. I strongly recommend you discuss in detail with your team of doctors whenever necessary.

(The author is Oncologist, Indraprastha Apollo Hospital, Delhi. He was previously Asst. Professor, National Cancer Institute, AIIMS Delhi. Views are personal)

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Male sex hormones may help treat breast cancer: Study

While endocrine therapy is standard-of-care for estrogen receptor positive breast cancer, resistance to these drugs is the major cause of breast cancer mortality.

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breast cancer

Sydney : Researchers have found new evidence about the positive role of androgens, commonly thought of as male sex hormones but also found at lower levels in women, in breast cancer treatment.

In normal breast development, estrogen stimulates and androgen inhibits growth at puberty and throughout adult life.

Abnormal estrogen activity is responsible for the majority of breast cancers, but the role of androgen activity in this disease has been controversial.

The new research published in the journal Nature Medicine showed that androgens have potential for treatment of estrogen receptor positive breast cancer.

A cancer is called estrogen receptor positive if it has receptors for estrogen, according to Breastcancer.org.

Using cell-line and patient-derived models, the global team, including researchers at the University of Adelaide and the Garvan Institute of Medical Research in Australia, demonstrated that androgen receptor activation by natural androgen or a new androgenic drug had potent anti-tumour activity in all estrogen receptor positive breast cancers, even those resistant to current standard-of-care treatments.

In contrast, androgen receptor inhibitors had no effect.

“This work has immediate implications for women with metastatic estrogen receptor positive breast cancer, including those resistant to current forms of endocrine therapy,” said lead researcher Theresa Hickey, Associate Professor at the University of Adelaide.

“We provide compelling new experimental evidence that androgen receptor stimulating drugs can be more effective than existing (e.g. Tamoxifen) or new (e.g. Palbociclib) standard-of-care treatments and, in the case of the latter, can be combined to enhance growth inhibition,” said Wayne Tilley, Director of the Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide.

Androgens were historically used to treat breast cancer, but knowledge of hormone receptors in breast tissue was rudimentary at the time and the treatment’s efficacy misunderstood.

Androgen therapy was discontinued due to virilising side effects and the advent of anti-estrogenic endocrine therapies.

While endocrine therapy is standard-of-care for estrogen receptor positive breast cancer, resistance to these drugs is the major cause of breast cancer mortality.

“The new insights from this study should clarify the widespread confusion over the role of the androgen receptor in estrogen receptor driven breast cancer,” said Elgene Lim, a breast oncologist and Head of the Connie Johnson Breast Cancer Research Lab at the Garvan Institute.

“Given the efficacy of this treatment strategy at multiple stages of disease in our study, we hope to translate these findings into clinical trials as a new class of endocrine therapy for breast cancer.”

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Azim Premji and Dr Devi Shetty chosen for PCB awards

Besides them 25 senior journalists have been selected for the ‘Press Club Annual Awards’, a release said.

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Azim Premji Wipro

Bengaluru, Jan 19: The chairman of Wipro Limited Azim Premji and the founder chairman of Narayana Health Dr Devi Prasad Shetty are among those who have been selected for the annual awards given by the Press Club of Bangalore.

Premji has been chosen for ‘Press Club Person of the Year’, while Dr Shetty and actor-Director Sudeep Sanjeev have been selected for the ‘Press Club Special Award.’

Besides them 25 senior journalists have been selected for the ‘Press Club Annual Awards’, a release said.

Chief Minister B S Yediyurappa will facilitate the awardees at a function scheduled for the third week of February, it said.

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Elizabeth Olsen: Nepotism creates fear that you don’t deserve the work you get

The actress added that she “always had this need to prove myself to everyone around me that I work really hard”, adding: “I couldn’t walk in a room without everyone already having an opinion.”

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Elizabeth Olsen

Los Angeles, Jan 19 : Hollywood star Elizabeth Olsen says she once thought of changing her surname and distance herself from the success of her family because it was insanity growing up in the spotlight.

“It was insanity. There were times when my sisters would always be spotted and I would be in the car with them and it would really freak me out. It has helped me navigate how I want to approach my career,” said the actress, whose older sisters are Mary-Kate Olsen and Ashley Olsen.

The actress added that she “always had this need to prove myself to everyone around me that I work really hard”, adding: “I couldn’t walk in a room without everyone already having an opinion.”

Elizabeth opened up om the fears of nepotism.

“The thing about nepotism is the fear that you don’t earn or deserve the work. There was even a part of me when I was a little girl that thought if I’m gonna be an actress I’m going to go by Elizabeth Chase, which is my middle name. And then, once I started working, I was like, ‘I love my family, I like my name, I love my sisters. Why would I be so ashamed of that?’ It’s fine now,” she said.

The actress said fame has made her more of a homebody.

“Fame has also made me someone who is more of a homebody than maybe I would like to be but I know where not to go. If I could do whatever I wanted for the day, I’d start with the gym, then I’d go to the grocery store, because it’s my favourite thing,” Elizabeth told The Sun.

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